I just want to be a quiet scholar

Chapter 464 Interesting Disciplines

"Lao Yan, if C01A continues to be double-nitrated, what do you think will be the next product?" Shen Qi asked.

Lao Yan said: "From theoretical analysis, the [3.2.1]-double-bridged ring core structure of benzazepine contains two functional groups of amine and aryl in a very close position, so I speculate that in electrophilic Under the reaction conditions of substitution, the electrophilic attack on the aromatic ring is protected by carbamate and amino group, and it is difficult to nitrate the aromatic ring even with a strong nitrating reagent. That is to say, the next step product is meaningless.”

"Simulate it." Shen Qi operated the computer and used Sybyl software to simulate.

The latest version of SybylPro is a computer-aided drug design software, based on the existing database, to assist in the completion of drug design, chemical combination schemes and other operations.

The simulated target product is a derivative of benzazepine, and the most matching commercial drug in the database is carbamazepine tablets.

Carbamazepine tablets are mainly used for analgesia, epilepsy, mania, psychosis, diabetes insipidus and other symptoms, and belong to the central nervous system drugs.

Lao Yan looked at the computer screen and said: "Is the next product of C01A meaningful? It is meaningless. Is this thing for treating mental illness?"

"It's really meaningless to imitate carbamazepine, but this is an auxiliary software after all, and it cannot be predicted with 100% accuracy. I feel that the next step of double nitrosation is of scientific research value. Try it, the experiment is to keep trying, said Maybe a blind cat ran into a dead mouse and got lucky." Shen Qi insisted on doing double nitrosation and began to prepare raw materials.

The boss is so stubborn, Lao Yan has nothing to do, so he can only do the preparations before the experiment with Shen Qi.

The preparatory work took a whole day, and the raw materials had to be reformulated and synthesized.

The next day, the experiment started, code-named C01B.

Shen Qi and Lao Yan went into battle together, and the protection of trifluoroacetamide was specially introduced to isolate the nitrogen atom, and prevent the formation of double-substituted cationic intermediates by dispersing the electron cloud density on the nitrogen.

This protection makes the nitration reaction take place further. At the same time, Shen Qi added a strong nitrating reagent, nitrotrifluoromethanesulfonic acid, which is specially used to overcome the slow nitration of benzazepine derivatives.

Two days had passed by this time, Shen Qi and Lao Yan took turns, and at any time in the laboratory, at least one of them was on duty.

Finally, the dinitro compound is condensed with glyoxal sodium bisulfite to obtain quinoxaline, and deprotected to obtain the target product.

The target product is a light blue crystal, crystal clear, beautiful and magical.

Shen Qi and Lao Yan were fascinated by its dreamy appearance, and the hard work of several days was not in vain.

"This is the charm of chemistry, a bunch of toxic raw materials, and finally create an incredible and beautiful product." Lao Yan covered himself tightly from his toes to the top of his head, and there was hardly an inch of bare skin on his whole body.

Shen Qi, who is also fully armed, observed the target product intently, and said: "Just looking at the appearance, C01B is more than one grade higher than C01A. This thing is not used for medicine, but it can be sold as an accessory and sell for a lot of money. "

Shen Qi and Lao Yan both know that for chemical products, appearance is more important than curative effect, which is the intrinsic nature of chemical products.

Through nuclear magnetic resonance, molecular weight determination and other chemical methods, Shen Qi and Lao Yan determined the molecular formula, molecular weight and molecular structure of C01B.

"So, its name is 4-oxo-5-phenyl-1-tetrahydro-3-methylene-4H-6-benzazepine, match it in the database , what is the closest commercial drug to C6B?"

The matching result given by Sybyl is: carbamazepine tablets.

"It shouldn't be, why is it carbamazepine again? The database hasn't been updated?" Lao Yan felt that the computer was fooling them.

"Look up the latest papers on organic chemistry and medicinal chemistry." Shen Qi suggested that he need to know the general pharmacological properties of C01B, otherwise it would be very blind to do animal experiments without a target.

After consulting a large amount of literature and consulting two senior professors from the School of Chemistry and the Department of Medicine, Shen Qi got a speculation that the main function of C01B should be to regulate the secretion of dopamine in the nucleus accumbens of the mesolimbic dopamine system. Basic Mechanisms of Addiction.

Shen Qi laughed loudly: "Chemistry is an interesting subject. The C01B obtained after the double nitrosation of the C01A you made from Old Smoke should theoretically be a chemical test product to restrain smoking addiction. Who the hell, you smoker, you're making a whole new smoking cessation compound!"

"Damn it?" Lao Yan was shocked, would he pay it back sooner or later?
Shen Qi's wording is very strict. He has been saying that C01B is a chemical test product, which theoretically has the effect of smoking cessation, but he did not say that it is a drug.

The C01B obtained in the preliminary test stage of the laboratory can only be regarded as a chemical test product. After passing various property tests, it is verified to be safe and effective, and it can be called a chemical commodity only after it is finally commercialized.

Drugs and chemical products with clearly marked prices on the market are all chemical commodities, and commodities mean that people have been widely recognized and are willing to pay for them.

The development of a new non-generic commercial drug requires a lot of hard work by many scientists. After a long period of experimental research and process verification, it will be possible to market it for the benefit of mankind.

Shen Qi and the others have three guns, one of which is mainly responsible for raising and dissecting animals. Only Shen Qi and Lao Yan are really engaged in innovative research.

Shen Qi said: "I think this C01B has potential for commercialization. As far as I know, there are not many real smoking cessation drugs on the market. The smoking cessation rate of NRT smoking cessation chewing gum is only 20%. Nicotinic acetylcholine receptor agonists Smoking cessation drugs have a higher success rate of smoking cessation, but smokers use this drug and quit smoking, but they have a certain degree of addiction to smoking cessation drugs.”

"Quitting smoking is very difficult. People who are determined to quit smoking, are there any things that they dare not do?" Lao Yan showed his own experience and touched the cigarette subconsciously.

"Are you addicted to smoking again?" Shen Qi smiled.

"I'm going out to smoke, go out to smoke." Lao Yan touched the cigarette box as a habitual action, but the cigarette was not with him, and it was locked in a locker outside the laboratory.

Shen Qi and Lao Yan came outside the laboratory together, and took off their masks and protective glasses.

Lao Yan noticed that Shen Qi was watching him with a mysterious smile, and he shivered, feeling chills and fear: "Boss, I can't quit smoking, don't use me as a human experiment!"

Shen Qi patted Lao Yan on the shoulder: "Making a brand-new commercial drug is a very arduous and lengthy job. If you can't make full use of external resources, you, me, and Lao Tu will not be able to make a commercial smoking cessation drug." Medicine. As for clinical trials, how could I do it on you? The last person I want to provoke is a chemist. If I test you today, you might poison me to death tomorrow."

"Chemists also have to abide by the law, right?" Lao Yan said, and then asked: "What should I do next?"

Shen Qi said: "There are more than one billion smokers in the world, and more than half of them have the desire to quit smoking. The C01B project is entrusted to you to follow up. You should study it further, collect more data, and then start animal experiments. .”

"Then you have to recruit a few assistants with me. Even in the initial stage of the laboratory test, I can't do enough by myself. You are very busy, so it is impossible to squat in the laboratory all day." Lao Yan made a request.

"You send out a few articles first, and there are no scientific research results. Why should I ask for someone?" Shen Qi said, and then asked with concern: "How is your relationship with Xiao Lian?"

Lao Yan talked about the matter: "If you don't add more experimenters to me, I can only stay in the laboratory. How can I have time to pick up girls?"

"Hehe, it's all over. It's okay, Lao Yan, keep working hard. The experimenter will not arrive so soon, so you bear it first. Experiment during the day and pick up girls at night. This rhythm is pretty good."

Shen Qi and Lao Yan came to the third floor, Shen Qi pointed to a small vacant room and said, "From today onwards, this is a smoking room, you can go and buy a cigarette butt recycling device with ventilation function, which is the kind of smoking room in the airport." Equipment, after you buy it, ask for financial reimbursement. But I still hope that you can quit smoking."

"Okay, long live, I understand." Old Yan was overjoyed, found a paper cup for some water, squatted in the empty room and started smoking.

Shen Qi came to the cafe and sat down to drink coffee.

There are not many people in the coffee shop, which shows that the center staff are very busy.

Shen Qi saw Wei Teng, Zhou Yu'an, and Xiao Junlong sitting at a certain table chatting together, with happy expressions on their faces.

Picking up the coffee cup, Shen Qi walked to the table of the three of them and sat down: "It seems that the NS equation project has made significant progress?"

"It's not that fast." Zhou Yu'an shook his head.

"Then you guys are smiling so happily?" Shen Qi asked.

(End of this chapter)