I just want to be a quiet scholar

Chapter 463 Benzazepines
The compound code-named C01A is white crystalline powder, insoluble in water, soluble in organic solvents such as acetone.

According to Lao Yan's report and Shen Qi's identification, the two of them can be sure that the main component of C01A is benzoazepines.

"Benzazepine, Lao Yan, you really belong to me." Shen Qi said.

The more well-known benzazepam drugs on the market include diazepam, oxazepam, etc. These drugs mainly play several roles: sedation, anti-anxiety, and hypnosis.

"C01A is indeed valuable, but it's not the kind of value I expected. But no matter what, it's also the result of your hard work in the past few months. Please compile a complete experimental report and let me have a look." Shen Qi couldn't help but Knowing how to evaluate Lao Yan, he arranged for Lao Yan to study the medicine for anemia. As a result, he came up with a product that was suspected to be sleeping pills + tranquilizers.

It cannot be said that Lao Yan's academic level is not good. For some reason, he designed a synthetic route and finally obtained C22A with a total yield of 01%, which is also a manifestation of high level.

Afterwards, Lao Tu next door gave Shen Qi an inspection report, which was about the analysis of the ADME properties of Shen Qi's self-made Le Luo Xian Fen.

Lao Tu has done a lot of experiments on monkeys and white mice in the past few months. The experimental data show that the skeleton structure of Shen Qi’s self-made Leluoxianfen is benzothiophene, the protein binding rate is greater than 95%, there is no CYP involved in metabolism, and the half-life is It is 1.15 days, and the metabolite is glucuronide.

Lao Tu's conclusion is that Shen Qi's self-made Le Luo Xian Fan can play a certain role in regulating estrogen in animals.But whether it can be equated with the American version of Le Luoxianfen still needs time to verify.

To verify a drug, in vivo experiments are necessary. Animal experiments are the first step. The key is clinical trials. After all, drugs are ultimately used to treat humans.

Shen Qi and his center have no conditions or qualifications to conduct clinical trials, so Lao Tu gave the above conclusion.

Shen Qi never thought of taking this test product and entrusting a qualified institution to do a clinical trial. He just practiced and accumulated pharmaceutical experience and data.

From theoretical research to laboratory preparation, to animal experiments, clinical trials, to obtaining approval from relevant departments and marketing, it is not so easy to launch a new drug.

Shen Qi, Lao Yan and Lao Tu, the three of them can only do animal experiments at present. They develop some chemical test products in small batches in the laboratory and accumulate experimental data on animals.

At five o'clock in the afternoon, Shen Qi called Lao Yan and set off to go on a blind date.

When he came downstairs, Lao Yan consciously sat in the driver's seat of Shen Qi's Mercedes-Benz SUV, and went out to eat with the leader, he must not let the leader drive.

Lao Yan drove to the entrance of the Shuyuan, waited with Shen Qi for a while, and saw two women coming out of the Shuyuan building.

One is a pregnant woman with her belly upright, and the other girl is supporting the pregnant woman.

"Dr. Ou is your wife, who is the short-haired one next to you?" Lao Yan asked.

"Xiao Lian, my wife's best friend." Shen Qi got out of the car, opened the back door, helped Ouye into the back row, and he also got into the back row, letting Xiao Lian take the passenger seat.

Shen Qi introduced everyone: "Yan Jun, a chemical engineer in our center. This beauty is Xiao Lian, an assistant researcher at the Chinese Academy of Sciences. By the way, Xiao Lian, what's your full name?"

Xiao Lian: "My full name is Lian Zilu."

"Lotus seed dew?" Lao Yan wanted to laugh when he heard it.

You old smoke, you always laugh when you meet, is Lianzilu funny?Shen Qi said: "It's a very sweet name, as the name suggests, Xiao Lian is a sweet girl. Let's go, Lao Yan drives, let's go."

The environment of the dining place is quiet and suitable for chatting.

Lao Yan is 1.7 meters five, not tall, not white, and does not have a prosperous beauty.His fingers were yellow from long-term smoking.

Xiao Lian is 1.5 meters eight, slightly fat, and a little white. Lao Yan didn't give her an amazing feeling, just an ordinary man in science and engineering.

Shen Qi made insinuations, euphemistically pointing out that Cinderella married Prince Charming, or a wage earner married Bai Fumei, these stories are all artistic treatment higher than reality.

In reality, most marriages are well-matched. The life experience, social status, and family background of the husband and wife are roughly the same, so the marriage can be long-term and stable.

For the sake of the matchmaker, Shen Qi felt that he had done his best. Whether there is any fate, Lao Yan and Xiao Lian, you two can decide for yourself.

"I had a good chat today, so how about it, Yan Gong, you can take a taxi later and send Xiaolian back. You can also carry out the second half of the event to deepen your understanding. Ouye and I have withdrawn first, and I have already bought the bill. I wish you all a good time." Shen Qi and his wife left early, leaving Lao Yan and Xiao Lian a space to be alone.

Back at the academician's villa, Ouye said: "In fact, every girl has a dream of Prince Charming."

Shen Qi: "But history tells us that princes basically marry daughters of noble families."

Ouye: "Can you stop being so realistic?"

"Ordinary girls may not be happy when they are with the prince." Shen Qi said.

"Yan Jun has no special features." As soon as Ouye returned home, he vetoed Shen Qi's solemnly launched old cigarette.

"Whether there are special features or not, it doesn't matter if you say it, Xiao Lian says it. I think they are quite suitable, and I have a better eye for people than you. Well, you go to bed early, and I will go to sleep after checking the information." Shen Qi helped Ouye up to the second floor and into the bedroom.

"Are you planning the unification of mathematics?" Ouye asked.

"The project has been approved." Shen Qi said.

Ouye said with great interest, "Who is on the project team?"

"I, Li Zhenqiang, it's just the two of us right now."

"Li Zhenqiang's major is algebraic geometry, who does number theory?"

Shen Qi patted his chest: "Your husband and I."

"You?" Ouye pinched Shen Qi's ear, and asked more and more curiously: "How far have you achieved in the number theory section?"

Shen Qi said modestly: "I haven't started to do it yet, because my level is limited, and I encountered many difficulties in the initial promotion process of the number theory section. After you give birth, I will specifically ask Dr. Ou, an expert in number theory, for relevant questions. But now, Dr. Ou's main task is to raise babies."

"Good boy." Ouye stroked Shen Qi's head, and then his stomach. The ones in front of her, her belly, her husband, and her children were her most important family members.

Mathematics is another spiritual sustenance of Ouye, but there will always be a period of time in a woman's life that she cannot concentrate all her energy on her favorite career.

A few days later, Lao Yan handed over to Shen Qi a chemical experiment report, which explained in detail the experimental process of C01A molecular design, synthetic route design, products and yields of each step, crystal preparation, etc. The conclusion is that my old Smoke has synthesized a new compound, but the specific use of this thing remains to be verified.

This is a chemistry paper. Lao Yan majored in chemistry. He has some knowledge of medicinal chemistry, but he is not a pharmacist or a medical scientist.

The writing method of medical papers is very different from Lao Yan’s chemical paper. Medical papers do not write many specific processes of drug preparation. Pharmacists and medical scientists pay more attention to drug resistance monitoring, clinical research, pharmacokinetics and BE. Research results in other professional fields.

So what specific use does C01A have, and whether it has scientific research value, Shen Qi needs to judge.

(End of this chapter)