Rebirth 1975: Tore up the call-back order at the beginning
Chapter 236: Successful Preparation of Fluoxetine
Sebei University. Chemistry Laboratory!
Zhou Yang has been here for two days, and now his research work has entered the most critical juncture.
Fluoxetine is a 5-ht reuptake inhibitor, which can selectively inhibit the reuptake of 5-ht by central neurons, promote transmitter conduction, boost spirits, improve mood, and produce antidepressant effects.
This drug has a very obvious effect on the treatment of depression, and has the characteristics of fast onset, long duration of action, no cardiovascular system effect, and weak anticholinergic effect.
Therefore, since its launch in 1987, it has rapidly replaced tricyclic antidepressant drugs.
Although the effect is very good, the preparation method of this medicine is very simple, and there are several methods for laboratory preparation alone.
The first method is to first use acetophenone, methylamine hydrochloride, and paraformaldehyde to carry out the Mannich reaction to generate 3-methylamino-1-phenylacetone hydrochloride, and then use potassium borohydride reduction in methanol to prepare 3 -Methylamino-1-phenylpropanol, synthesized fluoxetine hydrochloride through etherification and salification.
The total yield of fluoxetine produced by this method is about 41%, which is very impressive.
The second method is to use 3-dimethylamino-1-phenylpropanol as raw material, chlorinated by thionyl chloride, and etherified with p-trifluoromethylphenol to obtain n.Methyl fluoxetine, and then carry out vonbraun demethylation reaction with ethyl chloroformate, undergo hydrolysis reaction, and salt-forming reaction to generate fluoxetine hydrochloride.
Both the ingredients and the preparation process are relatively simple!
With Zhou Yang's theoretical level and hands-on ability, there is really no challenge in preparing this medicine.
The only thing that gave Zhou Yang a headache was that although the chemistry laboratory of Saibei University was the most advanced in the province, it was still a bit inferior.
In addition, their maintenance is not very good, the accuracy of many instruments and equipment has errors, and the actual situation is not very good.
Therefore, after arriving at the laboratory yesterday, the first thing Zhou Yang did was not to prepare medicines, but to adjust and calibrate these instruments.
You must know that a chemical experiment is like solving a math problem, the difference is a thousand miles away!
Even a difference of a few milligrams in dosage can produce completely different results.
Therefore, before the actual preparation of the drug, it is necessary to calibrate these instruments and equipment accurately.
However, Zhou Yang's behavior immediately aroused the dissatisfaction of the head of the chemistry laboratory of Sebei University.
In his opinion, you are here to do experiments, you are here to make trouble!
It's just that once an expert makes a move, he will know if there is one!
After watching Zhou Yang's next operation, he was quickly conquered.
It took half a day for Zhou Yang to calibrate most of the equipment in the laboratory, and only started to prepare fluoxetine after reaching the standard.
Zhou Yang used the first method. Although this method is more complicated, it is more effective.
Time passed by every minute and every second. Seeing that the 3-methylamino-1-phenylpropanol in the equipment was etherified, salted, and then condensed into white powder, Zhou Yang finally breathed a sigh of relief.
This is the first time he has prepared medicine after his rebirth. Although he has the experience of his previous life, it is still somewhat difficult in the current experimental environment.
Fortunately, everything was safe and sound, and he succeeded!
The next step is to repeat the previous steps. After all, Lin Wanwan's illness is not serious, and the amount needed is not small.
Normally, when fluoxetine is used for the treatment of depression, 20 mg is taken orally once a day.
If the condition is serious, it can be gradually increased to 60-80 mg per day as needed.
Based on Zhou Yang's estimate of Lin Wanwan's condition, she needs at least two months of medicine to alleviate her condition, and to recover, she needs to take medicine for at least half a year to a year.
And it is obviously impossible for him to come to prepare this medicine for her often, so if there is a chance, then make more.
Three days later, when Zhou Yang came out of the laboratory, he had successfully prepared 10 grams of fluoxetine, which is 10000mg.
According to Lin Wanwan's situation, it's almost enough for her to last for a year or so.
And in order to make it easier for her to take it, Zhou Yang combined these fluoxetine with other medicines to make hundreds of tablets the size of "Analgin".
Although I don't know if these pills can cure Lin Wanwan's illness, Zhou Yang tried his best.
As for the others, it can only depend on Lin Wanwan's own good luck!
In addition, before leaving, Zhou Yang had already written a letter to Lin Wanwan's family.
In the letter, Zhou Yang briefly described Lin Wanwan's experience over the years and the current situation, hoping that her parents and relatives could come and take care of her for a while.
Zhou Yang has personally experienced Lin Wanwan's case, and knows that Chen Jin has been asking Lin's father and Lin's mother for money through various means over the years, and he succeeds every time.
This shows that Lin's father and Lin's mother love Lin Wanwan, and they will definitely come after knowing what happened to her.
I also hope that with the company and care of her parents and family, she can get better!
.......
The preparation of fluoxetine was finally completed, so Zhou Yang planned to stay in Qingcheng for another day before returning to Yunshan County.
In addition to preparing special medicine for Lin Wanwan this time, he also had another task in Qingcheng, which was to purchase the equipment needed for the biogas digester.
After all, after the biogas digester is built, it cannot be used directly. It needs to be transported through pipelines and then undergo secondary treatment.
For example, biogas power generation requires biogas generators!
Whether it's plastic pipes or biogas generators, Yunshan County doesn't have any, and Ning City is not enough.
Now that he came to the provincial capital, Zhou Yang planned to buy all these things back.
But Zhou Yang is not very familiar with Qingcheng!
More importantly, in this era, it is not possible to buy what you need with money.
Many materials are in short supply, and must be approved by the above.
It is not even possible to approve a note for some things, and it must be customized from the manufacturer.
Not only is it expensive, but it often takes months to wait.
After thinking about it again and again, Zhou Yang could only turn to Yang Yunzhao for help. After all, he is the dean of the department of Saibei University, and he has the right to purchase some equipment and instruments.
In the past few days, Yang Yunzhao organized the teachers in the department to conduct a detailed review of the seven textbooks translated by Zhou Yang.
All the teachers and professors thought that Zhou Yang's translation was of a very high level, so they decided to use the content of these textbooks as the basis and combine the current level of the students to compile a new set of chemistry textbooks suitable for the students of Saibei University.
However, these things are all handled by professionals, and there is no need for the chief director, Yang Yunzhao, to do it himself.
After hearing Zhou Yang's request, Yang Yunzhao naturally would not refuse.
In his eyes, Zhou Yang is a real precious talent!
Being able to translate seven textbooks within one month, not only the translation speed is fast, but the quality is also very high.
No matter where such people are placed, they are top elites who need to be recruited by scientific research institutes.
And now they have only finished translating the freshman textbooks, and there are sophomore, junior and senior textbooks waiting to be translated.
In addition, the director (principal) of the school's revolutionary committee also said that in addition to their chemistry department, the physics department, mathematics department, architecture department, and biology department also have a large number of professional books waiting for translation.
All in all, Zhou Yang was well served!
Therefore, Yang Yunzhao never refused Zhou Yang's request and fully cooperated.
And with Yang Yunzhao's help, Zhou Yang's material procurement mission went smoothly, and he got everything soon.
Afterwards, Zhou Yang was ready to return!
ps: Chapter 2 has been delivered, and Chapter 3 is still being created, and it will be sent in the afternoon!
After the endless coma, Shi Yu suddenly got up from the bed.
He took a big gulp of fresh air, his chest trembling.
Confused, puzzled, all kinds of emotions came to my mind.
where is this?
Afterwards, Shi Yu subconsciously observed his surroundings, and then became even more at a loss.
A single dormitory?
Even if he was successfully rescued, he should be in the ward now.
And my own body... How come there is no injury at all.
With doubts, Shi Yu quickly swept his gaze across the room, and finally settled on a mirror by the bedside.
The mirror reflected his current appearance, he was about seventeen or eighteen years old, and he was very handsome.
But the problem is, it's not him!
My previous self was a handsome young man in his 20s who had been working for a while.
But now, no matter how you look at it, this appearance is only the age of a high school student...
This change left Shi Yu in a daze for a long time.
Don't tell him that the operation was a success...
The body and appearance have changed. This is not a question of whether to have surgery or not, but a fairy art.
He turned into a completely different person!
Could it be... that he crossed over by himself?
In addition to the mirror on the bedside which was obviously placed in a bad feng shui position, Shi Yu also found three books beside it.
Shi Yu picked it up and took a look, the title made him silent for an instant.
"Necessary Beast Breeding Handbook for Novice Breeders"
"Postpartum Care of Pet Animals"
"Guidelines for Evaluation of Alien Beast Ear Girls"
Shi Yu:? ? ?
The titles of the first two books are quite normal, what's the matter with you in the last one?
"cough."
Shi Yu's eyes were serious, and he stretched out his hand, but soon his arm stiffened.
Just when he was about to open the third book to see what it was, his brain suddenly felt a sharp pain, and a large amount of memories flooded in like a flood.
Icefield City.
Pet breeding base.
Trainee pet keeper.To provide you with the rebirth of the great god Cangyue 1975: tearing up the order of returning to the city at the beginning
Beastmaster?
Zhou Yang has been here for two days, and now his research work has entered the most critical juncture.
Fluoxetine is a 5-ht reuptake inhibitor, which can selectively inhibit the reuptake of 5-ht by central neurons, promote transmitter conduction, boost spirits, improve mood, and produce antidepressant effects.
This drug has a very obvious effect on the treatment of depression, and has the characteristics of fast onset, long duration of action, no cardiovascular system effect, and weak anticholinergic effect.
Therefore, since its launch in 1987, it has rapidly replaced tricyclic antidepressant drugs.
Although the effect is very good, the preparation method of this medicine is very simple, and there are several methods for laboratory preparation alone.
The first method is to first use acetophenone, methylamine hydrochloride, and paraformaldehyde to carry out the Mannich reaction to generate 3-methylamino-1-phenylacetone hydrochloride, and then use potassium borohydride reduction in methanol to prepare 3 -Methylamino-1-phenylpropanol, synthesized fluoxetine hydrochloride through etherification and salification.
The total yield of fluoxetine produced by this method is about 41%, which is very impressive.
The second method is to use 3-dimethylamino-1-phenylpropanol as raw material, chlorinated by thionyl chloride, and etherified with p-trifluoromethylphenol to obtain n.Methyl fluoxetine, and then carry out vonbraun demethylation reaction with ethyl chloroformate, undergo hydrolysis reaction, and salt-forming reaction to generate fluoxetine hydrochloride.
Both the ingredients and the preparation process are relatively simple!
With Zhou Yang's theoretical level and hands-on ability, there is really no challenge in preparing this medicine.
The only thing that gave Zhou Yang a headache was that although the chemistry laboratory of Saibei University was the most advanced in the province, it was still a bit inferior.
In addition, their maintenance is not very good, the accuracy of many instruments and equipment has errors, and the actual situation is not very good.
Therefore, after arriving at the laboratory yesterday, the first thing Zhou Yang did was not to prepare medicines, but to adjust and calibrate these instruments.
You must know that a chemical experiment is like solving a math problem, the difference is a thousand miles away!
Even a difference of a few milligrams in dosage can produce completely different results.
Therefore, before the actual preparation of the drug, it is necessary to calibrate these instruments and equipment accurately.
However, Zhou Yang's behavior immediately aroused the dissatisfaction of the head of the chemistry laboratory of Sebei University.
In his opinion, you are here to do experiments, you are here to make trouble!
It's just that once an expert makes a move, he will know if there is one!
After watching Zhou Yang's next operation, he was quickly conquered.
It took half a day for Zhou Yang to calibrate most of the equipment in the laboratory, and only started to prepare fluoxetine after reaching the standard.
Zhou Yang used the first method. Although this method is more complicated, it is more effective.
Time passed by every minute and every second. Seeing that the 3-methylamino-1-phenylpropanol in the equipment was etherified, salted, and then condensed into white powder, Zhou Yang finally breathed a sigh of relief.
This is the first time he has prepared medicine after his rebirth. Although he has the experience of his previous life, it is still somewhat difficult in the current experimental environment.
Fortunately, everything was safe and sound, and he succeeded!
The next step is to repeat the previous steps. After all, Lin Wanwan's illness is not serious, and the amount needed is not small.
Normally, when fluoxetine is used for the treatment of depression, 20 mg is taken orally once a day.
If the condition is serious, it can be gradually increased to 60-80 mg per day as needed.
Based on Zhou Yang's estimate of Lin Wanwan's condition, she needs at least two months of medicine to alleviate her condition, and to recover, she needs to take medicine for at least half a year to a year.
And it is obviously impossible for him to come to prepare this medicine for her often, so if there is a chance, then make more.
Three days later, when Zhou Yang came out of the laboratory, he had successfully prepared 10 grams of fluoxetine, which is 10000mg.
According to Lin Wanwan's situation, it's almost enough for her to last for a year or so.
And in order to make it easier for her to take it, Zhou Yang combined these fluoxetine with other medicines to make hundreds of tablets the size of "Analgin".
Although I don't know if these pills can cure Lin Wanwan's illness, Zhou Yang tried his best.
As for the others, it can only depend on Lin Wanwan's own good luck!
In addition, before leaving, Zhou Yang had already written a letter to Lin Wanwan's family.
In the letter, Zhou Yang briefly described Lin Wanwan's experience over the years and the current situation, hoping that her parents and relatives could come and take care of her for a while.
Zhou Yang has personally experienced Lin Wanwan's case, and knows that Chen Jin has been asking Lin's father and Lin's mother for money through various means over the years, and he succeeds every time.
This shows that Lin's father and Lin's mother love Lin Wanwan, and they will definitely come after knowing what happened to her.
I also hope that with the company and care of her parents and family, she can get better!
.......
The preparation of fluoxetine was finally completed, so Zhou Yang planned to stay in Qingcheng for another day before returning to Yunshan County.
In addition to preparing special medicine for Lin Wanwan this time, he also had another task in Qingcheng, which was to purchase the equipment needed for the biogas digester.
After all, after the biogas digester is built, it cannot be used directly. It needs to be transported through pipelines and then undergo secondary treatment.
For example, biogas power generation requires biogas generators!
Whether it's plastic pipes or biogas generators, Yunshan County doesn't have any, and Ning City is not enough.
Now that he came to the provincial capital, Zhou Yang planned to buy all these things back.
But Zhou Yang is not very familiar with Qingcheng!
More importantly, in this era, it is not possible to buy what you need with money.
Many materials are in short supply, and must be approved by the above.
It is not even possible to approve a note for some things, and it must be customized from the manufacturer.
Not only is it expensive, but it often takes months to wait.
After thinking about it again and again, Zhou Yang could only turn to Yang Yunzhao for help. After all, he is the dean of the department of Saibei University, and he has the right to purchase some equipment and instruments.
In the past few days, Yang Yunzhao organized the teachers in the department to conduct a detailed review of the seven textbooks translated by Zhou Yang.
All the teachers and professors thought that Zhou Yang's translation was of a very high level, so they decided to use the content of these textbooks as the basis and combine the current level of the students to compile a new set of chemistry textbooks suitable for the students of Saibei University.
However, these things are all handled by professionals, and there is no need for the chief director, Yang Yunzhao, to do it himself.
After hearing Zhou Yang's request, Yang Yunzhao naturally would not refuse.
In his eyes, Zhou Yang is a real precious talent!
Being able to translate seven textbooks within one month, not only the translation speed is fast, but the quality is also very high.
No matter where such people are placed, they are top elites who need to be recruited by scientific research institutes.
And now they have only finished translating the freshman textbooks, and there are sophomore, junior and senior textbooks waiting to be translated.
In addition, the director (principal) of the school's revolutionary committee also said that in addition to their chemistry department, the physics department, mathematics department, architecture department, and biology department also have a large number of professional books waiting for translation.
All in all, Zhou Yang was well served!
Therefore, Yang Yunzhao never refused Zhou Yang's request and fully cooperated.
And with Yang Yunzhao's help, Zhou Yang's material procurement mission went smoothly, and he got everything soon.
Afterwards, Zhou Yang was ready to return!
ps: Chapter 2 has been delivered, and Chapter 3 is still being created, and it will be sent in the afternoon!
After the endless coma, Shi Yu suddenly got up from the bed.
He took a big gulp of fresh air, his chest trembling.
Confused, puzzled, all kinds of emotions came to my mind.
where is this?
Afterwards, Shi Yu subconsciously observed his surroundings, and then became even more at a loss.
A single dormitory?
Even if he was successfully rescued, he should be in the ward now.
And my own body... How come there is no injury at all.
With doubts, Shi Yu quickly swept his gaze across the room, and finally settled on a mirror by the bedside.
The mirror reflected his current appearance, he was about seventeen or eighteen years old, and he was very handsome.
But the problem is, it's not him!
My previous self was a handsome young man in his 20s who had been working for a while.
But now, no matter how you look at it, this appearance is only the age of a high school student...
This change left Shi Yu in a daze for a long time.
Don't tell him that the operation was a success...
The body and appearance have changed. This is not a question of whether to have surgery or not, but a fairy art.
He turned into a completely different person!
Could it be... that he crossed over by himself?
In addition to the mirror on the bedside which was obviously placed in a bad feng shui position, Shi Yu also found three books beside it.
Shi Yu picked it up and took a look, the title made him silent for an instant.
"Necessary Beast Breeding Handbook for Novice Breeders"
"Postpartum Care of Pet Animals"
"Guidelines for Evaluation of Alien Beast Ear Girls"
Shi Yu:? ? ?
The titles of the first two books are quite normal, what's the matter with you in the last one?
"cough."
Shi Yu's eyes were serious, and he stretched out his hand, but soon his arm stiffened.
Just when he was about to open the third book to see what it was, his brain suddenly felt a sharp pain, and a large amount of memories flooded in like a flood.
Icefield City.
Pet breeding base.
Trainee pet keeper.To provide you with the rebirth of the great god Cangyue 1975: tearing up the order of returning to the city at the beginning
Beastmaster?
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