my life simulator

Is CAR-T technology mature enough to be applied?

Is Lu Li telling me that he has conquered cancer?

Professor He took a deep breath, only feeling that his heart was about to burst.

"I think this technology is already mature. You should take a look first!"

Lu Li had already done a human experiment. Although it was a virtual human experiment, it was no different from a real human experiment.

This technology has been proven!

"Okay! I'll take a look first!"

Professor He took a sip from the teacup, trying to suppress the shock and excitement in his heart, but... the hand holding the teacup was trembling!

After calming down, Professor He opened the thesis and read it carefully from beginning to end.

After reading it this time, Professor He almost knocked over his teacup!

Modify T cells to calibrate the genetic characteristics of cancer cells.This step is the technology disclosed by CAR-T, and people who study this project all over the world know this step.

Then came the second step, Lu Li made some modifications on the T cells, blocking the T cells' information transmission mechanism, so that the T cells would no longer "call for allies".

This step has been disclosed by Lu Li in his previous paper, and it has been verified by major scientific research institutions all over the world. It is even the best method for treating terminal cancer patients in countless cancer hospitals.

Now, in Lu Li's paper, the third step is given, which is to modify the gene of the B cells, shield the command ability of the B cells, and make it no longer release immune factors crazily.

From a theoretical analysis, this is a feasible solution.

After closing the paper, Professor He opened the next experiment report.

In the experiment report, Lu Li described all the operation steps in detail and wrote out all the experimental data.

This experimental report is very detailed, and the experiment can be repeated based on the experimental report.

Of course, Lu Li did not write down the data of the human experiment. After all, it is not that easy to do human experiments in reality.

After reading the thesis and the experiment report, Professor He raised his eyes to look at Lu Li, the expression on his face was still a bit dull.

"So... the cancer has been conquered by you?"

After being dazed for a while, Professor He suddenly burst into laughter: "Hahahaha! My student has already conquered cancer!"

"This is a great scientific achievement! From today, cancer is no longer a nightmare for mankind!"

Chapter 358 We Are Witnessing History

"Come on, let's go to the Cancer Research Institute!"

After reading Lu Li's thesis, Professor He got up quickly, "Let's go to the laboratory to verify it."

If it is an irrigation paper, naturally there is no need for verification.Lu Li's scientific research has extremely high value, and it can even be said to be a groundbreaking great achievement. Naturally, it has to go through comprehensive and meticulous verification.

So, Professor He and Lu Li hurried out of the office and rushed all the way to the Fudan Cancer Institute.

"Old Guo, Lao Guo, come quickly!"

Walking into the Cancer Research Institute, Professor He raised the thesis materials in his hand and shouted all the way at the top of his voice.

"I'm here! I'm here!"

Professor Guo popped his head out from the door of the office.

Seeing Professor He running over excitedly, followed by Lu Li, Professor Guo quickly asked, "Old He, why are you yelling so much?"

"Lu Li has released the research results, quickly organize people to verify it."

Professor He walked like flying, shouting as he walked.

Research results?

Hearing Professor He's words, Professor Guo was taken aback for a moment, and looked at Lu Li with a bit of horror.

This is the result?

It has only been more than two months since the last time the improvement plan of CAR-T technology was released?Has it worked again?

The graduate students and doctoral students who were busy next to him also stopped one by one, looked at Lu Li, and thought to themselves: What the hell are you producing again?

"Old Guo, come and see!"

Professor He's face was full of red, and he walked like flying. He walked into Professor Guo's office in a few steps, and stuffed the paper materials into Professor Guo's hand, "Quick, organize verification."

"Why panic? I'll take a look first!"

Professor Guo was quite calm, ignored Professor He's yelling, and started to read the paper after receiving it.

"Application of gene editing technology for T cells and B cells in CAR-T technology."

application?

Seeing this keyword, Professor Guo's eyes twitched a few times.Dare to write application in the title, could it be... Lu Li is sure that this technology is mature?

CAR-T technology is mature, what is this concept?

As the research leader of the Cancer Research Center, how can Professor Guo not know about CAR-T technology?

This new technology, which is still in the exploratory stage, once it matures, it will be... a special drug for cancer treatment, and the most reliable technology for cancer treatment.

From a clinical point of view, this is considered to have conquered cancer!

If this technology is real, if it is really feasible and reliable after verification, then... Lu Li's scientific research achievement will be a great historical breakthrough!

We are witnessing history!

Professor Guo's heart was filled with huge waves, and the hands holding the materials were trembling slightly.

Taking a deep breath, Professor Guo adjusted his glasses and looked at the paper seriously.

One word at a time, carefully, and earnestly study.

Modify T cells to put cancer cells on the "hostile list" and weaken the ability of T cells to "call friends."This is the result of Lu Li's previous research.

Now, in this paper, Lu Li gave a new idea.On the basis of modifying the genes of the T cells, Lu Li further modified the genes of the B cells, making the B cells shielded from "logistics and command capabilities".

In theory, Lu Li's idea is correct and feasible.

It's just... to achieve this goal, it involves very specific gene editing modification technology.

To accurately modify a certain function of B cells, a very specific and precise gene editing operation is required. It is very likely... that the genetic manipulation of modifying a certain function of B cells will not be possible for a long time.

"The idea is right."

After finishing the paper, Professor Guo nodded, and then glanced at Professor He and Lu Li, "However, it's too early to talk about application? This is just a directional theoretical research paper, and it can't be applied in practice yet." link."

Putting down the paper in his hand, Professor Guo glanced at Lu Li and the two again, and said, "To accurately edit the genes of B cells, it will take a long time of research to find the exact gene targets and select the genes we want to edit. Fragment. Let’s do some research on this first.”

"no need!"

Professor He smiled, and took out another document, "The experiment has been done. This is the experiment report."

"Uh?"

Professor Guo's eyes widened, "Have you made it?"

He hurriedly snatched the experiment report from Professor He, and Professor Guo read it seriously again.

In this experiment report, Lu Li wrote down every step of the experiment in detail, including reaction time, ambient temperature, humidity, readings of equipment and meters, and other detailed data.

This... actually succeeded?

Lu Li has completed all the experimental steps, and there is only one result that needs to be verified.

Professor Guo raised his head to look at Lu Li, the corners of his mouth trembling, "You... have completed all the techniques for genetic modification of B cells?"

"Yes!"

Lu Li nodded, "We came here this time to verify the results on your side."

"In more than two months, the B cell gene editing technology was developed. How did you find the gene fragment? How did you locate it?"

Professor Guo still couldn't believe it.

I did my first experiment in the virtual laboratory!

In the real world for more than two months, I did not know how many experiments were performed in the virtual laboratory, and I did not know how much time it took to find the gene fragment.

Of course, Lu Li couldn't say that. He could only say, "Maybe it's luck? I happened to find the gene fragment needed for gene editing of B cells."

luck……

This reason was so powerful that Professor Guo was speechless.

Research is a process of trial and error.In this infinite trial and error process, luck comes first.

If you are unlucky, you may not be able to find the desired gene fragment from the 30 billion base pairs in a year, two years, or even ten years.

If you're lucky... maybe like Lu Li, you'll find your target in just over two months.

So, even scientists have to talk about luck.

"Go! We will verify right away!"

Professor Guo didn't worry about luck, got up quickly, walked out of the office, and yelled at the busy postgraduates and doctoral students outside: "Stop what you're doing, go to the genetic laboratory immediately, and do a scientific research verification, hurry up!"

Is it the verification of scientific research results?

Another verification of Lu Li's scientific research results?

They are all hard-working scientific research dogs. We can only follow the instructor to mix experience, but you continue to produce scientific research results.

It's really... It hurts my self-esteem too much!

The scientific research dogs driven by Professor Guo ran up one by one, but when they passed by Lu Li, they lowered their heads slightly.

When everyone came to the genetic laboratory, Professor Guo asked Lu Li to lead the experiment and directed many scientific research dogs to do the experiment.

A group of graduate students and doctoral students worked for Lu Li, continuously extracting B cell samples, preparing transcriptase, and preparing cut proteins.

Lu Li sat in front of the test bench, and various experimental materials were poured into Lu Li's hands continuously.

Turning on the electron microscope and turning on the gene gun, Lu Li continued to edit the B cells, making samples one by one, more than 100 times in a row.

"The test passed! The genetically modified specimen has been obtained."

After Lu Li had done more than 100 genetic modifications, Professor Guo, who carried out tests later, had already found a B cell sample that had accurately completed the genetic modification.

"Successful! The B cell gene editing technology has been successfully verified!"

Professor He next to him couldn't help cheering.

"congratulations!"

"Lu Li, congratulations!"

There was a burst of applause in the laboratory, and everyone congratulated Lu Li on his successful technical verification.

This verification proved that Lu Li's B cell gene editing technology was successful.

As for more than 100 times to accurately prepare the required genetic modification specimens, this is quite normal.

With the current gene editing technology, even if the gene segment to be edited is identified, it is impossible for the shear protein and transcriptase to accurately cut the desired position at one time, and often cut the wrong place.

After a hundred experiments, one specimen with correct gene editing can be obtained. This is the reason why Lu Li confirmed the experimental data. This result is already very good.

If there is no such experimental data, I don't know how many years of experiments will be done before I happen to hit the right spot!

"B cell gene editing technology has passed the verification!"

Professor Guo also announced the results with excitement, and then said: "The next thing to do is to verify the CAR-T anti-cancer technology."

"This verification will take some time."

Professor He took the conversation, turned to Lu Li with a smile and said, "However, your theoretical research paper can be published. The experimental data must be kept secret!"

"understand!"

Lu Li nodded, "I still need to ask Professor Guo to arrange the verification of the results of the anti-cancer technology."

"no problem."

Professor Guo agreed without hesitation.

……