Auto chess in the operating room

Chapter 322 The Value of "Cell" Magazine
After Tanglou returned to the dormitory, he directly redeemed and upgraded to the animal experiment theory (two stars, 9), and then began to write the paper "The Effect of Cyclophosphamide (CP) and Colchicine (COL) on Traditional Kunbai mouse chromosomal aberration experiments and theoretical research on breeding improved ICR mouse inbred strains."

Under the two-star technique, Tang Lou wrote a paper of more than 6000 words very smoothly. After the paper, Tang Lou theoretically discussed the experimental method of improving mice, created a new system, and The traits and advantages of the new generation of improved ICR mice are introduced emphatically. They have good motherhood, particularly docile temperament, strong physique and rapid growth.

After completing the thesis, Tang Lou directly submitted this piece of theoretical research to the "Cell" magazine.

"Cell", "Nature" and "Science" have become the three most authoritative journals in the world.

These three journals are the journals that most researchers most expect their work to be published in. Two established journals, Nature and Science, publish articles in a wider range of disciplines.

Since "cell" was founded in 1976, it has become one of the most famous journals in the field of natural science research in the world. "celll" mainly publishes important original scientific research reports, and many of the most important discoveries in the field of life sciences All published in "cell".

For example, the very famous "artemisinin" in China: it originated from the discovery of the Chinese herbal medicine garden, and this article was published on it. It was through this method that Tu Aoao and her colleagues caused a huge sensation in the world.

As another example, another very famous article analyzed the relationship between population genomes and the complex framework of human diseases, arguing that the large amount of data obtained from whole genome sequencing, the Thousand Genomes Project, and targeted genome sequencing revealed a wealth of rare , individual mutations, which may account for the greater impact of recent mutations on disease susceptibility and protection than ancient mutations.

And so on various important research results, many of the world's big cows have published papers on it.

After Tang Lou submitted his manuscript, he began to design his own topic, and then reported to Professor Liu.

At the same time, on the other side of the ocean, an editor of the "Cell" magazine in the United States received a paper submission from Huaguo. After reading it, he found it very interesting. If the ICR mouse inbred line proposed by the author If it is really as good as he introduced, it can completely replace the white mouse in the experimental animal world and become the gold standard in the industry.

This was an epoch-making event. The editor smelled the unusualness, immediately printed out the paper, and walked into the office of the editor-in-chief Alex.

Alex, who is over 60 years old this year, has eye-catching blond hair and a tough facial line that looks like a knife and an axe. His whole person gives off a sense of authority, and he is reviewing some papers very seriously.

Alex is very well-known and influential in the world, and his own resume is also shining. He just retired from the position of technical consultant of Johnson & Johnson and joined "Cell" magazine. He is an extremely prestigious , is also a very courageous editor-in-chief, and also the director of the research institute affiliated to "cell".

Seeing the little editor knocking on the door and coming in, Alex looked up and seemed a little dissatisfied: "Didn't I say that I'm picking the cover article for the next issue these two days, don't come in and disturb me if there's nothing important."

The editor handed over the printout of the thesis in his hand: "Editor-in-Chief, this paper is very interesting, I think you will be interested."

The editor is very familiar with Alex's temper, and he is full of passion and keenness for such groundbreaking papers and research.

Alex was a little surprised. He took the paper from the editor and glanced at the author. It turned out to be a doctor from China. He was a little surprised. Then he opened the content and read it carefully.

After reading it soon, Alex put down the thesis, pondered for a while, then picked it up and read it again.

"The ICR mouse inbred strain surpasses all the inbred strains cultivated in the world in traits. If this can be achieved, it will probably cause a sensation in the animal experiment world."

With Alex's insight, of course, I understand the influence of this paper, which is definitely epoch-making.

More than two-thirds of animal experiments use mice, so an inbred strain of mice with better traits and more stability is enough to make all pharmaceutical companies and scientific research units crazy about it.

The "Cell" journal, in addition to its editorial department, also has a subordinate research institute, which has part-time experts and researchers in various disciplines. It is a top scientific research institution in a multidisciplinary field.

The source of funds for the institute is various pharmaceutical giants such as Pfizer, Johnson & Johnson, and GlaxoSmithKline, which are extremely authoritative internationally.

After reading Tang Lou's thesis, Alex had a crazy idea in his mind, that is, to conduct verification experiments through the research institute affiliated with Cell, as long as the excellent characteristics of the ICR mouse inbred strain are confirmed, then he will immediately start creating animals The new gold standard for testing mouse inbred strains in the experimental field, an authoritative new international standard.

In the future, all mice produced by animal companies must use ICR mice as the standard.

Alex thought for a while and said directly: "You print out ten copies of this paper, and at the same time, notify all the heads of the institute to be present. I'm going to hold a large-scale academic exchange meeting of the institute."

At this time, Tang Lou had also sorted out the first draft of his project.

When I came to Professor Liu Juzi's office and saw Tang Lou, Professor Liu was of course looking forward to it.

"Tang Lou, how is your subject preparation?"

Tang Lou directly handed his first draft to Professor Liu, and said, "Professor Liu, I have changed my mind. I am going to put aside the research and development of high blood pressure drugs first. This time I proposed the subject: "In the laboratory, for Evaluation of traits, stability and superiority of the improved ICR mouse inbred line compared with the traditional Kunming white mouse""

"ICR mice?"

Professor Liu was at a loss. She was naturally very familiar with the field of animal experiments, but she had never heard of ICR mouse inbred strains.

"The so-called improved ICR mouse is a new inbred strain that my subject plans to study and improve."

Tang Lou said directly.

"Are you going to improve the experimental mice, and then evaluate and study the traits, stability, and superiority of the mice?"

Professor Liu was shocked by Tang Lou again, why does this kid think so wildly?

"Professor Liu, in fact, I already have a preliminary theoretical research foundation, and now I need the laboratory to induce the first batch of ICR mice. I have established a cooperation agreement with the Jin Group in Shanghai, and the other party has provided me with five hundred In the flat mouse house, as long as the first batch of mice can leave the laboratory, I will be able to breed a large number of ICR mice in the experimental base of the Jin Group. My project this time is to ask the teachers and students of the whole school to cooperate with me. These inbred strains of ICR mice were scored and evaluated."

"I am willing to provide [-] improved ICR mice to the college for free. I will also fund the entire project at my own expense later on. The only requirement is that my laboratory be provided to induce the first batch of mice."

Tang Lou directly showed his hole card.

To be honest, for the teachers and students of the college, the general project funding is only [-] to [-], and the experimental mice often take up [-] to [-]. If someone can provide mice for free, they are of course very willing.

In itself, this kind of evaluation experiment is very simple to operate, all that is needed is to record the performance of the ICR mice in the experiment.

And the final huge data is sorted out and analyzed by Tang Lou himself.

Hearing Tang Lou's plan, Professor Liu was also a little excited. This guy Tang Lou dared to think too much, and he was very operable.

But the only question is whether this so-called improved ICR mouse is worth the effort to mobilize all the teachers and students of the school for evaluation.

If the inbred strain of ICR mice is not as good as Tang Lou imagined, all follow-up work will be a waste of time.

And this topic will also become a huge laughing stock.

"Tang Lou, like this, I will seek the opinions of other tutors for your project plan, and I need to digest it. It happens that there is still some time before your opening report, so I will come here first."

Professor Liu waved his hand to let Tang Lou go out first.

Looking at the first draft of the project on the table, Professor Liu muttered to himself: "ICR mouse inbred strain? This brat really dares to do and think. It's a headache."

(End of this chapter)