Auto chess in the operating room

Chapter 318 Tang Lou's First Pot of Gold
Tang Lou was directly equipped with the theory of animal experiments (one star, 3), and countless information and materials entered his mind.

Animal experimentation is the most critical and core step in the entire process of new drug development, and it is also a bridge for innovation in medicine and technology.

Equipped with the theory of animal experiments, Tang Lou directly began to simulate various animals in the laboratory, and soon the common Caenorhabditis elegans, fruit flies, zebrafish, medaka fish, Xenopus laevis, chickens, rats, guinea pigs , hamster, rabbit, tree shrew, pig, cow, buffalo, goat, sheep, ferret, cat, dog, marmoset, cynomolgus monkey, macaque, etc.

A very representative animal appeared in the laboratory, and for a while, the laboratory seemed to become a zoo.

Among these animals, macaques can be said to be the closest animals to humans within the limits of animal ethics, and are widely used in neuroscience, stem cell science and infectious disease.

Of course, among these animals, mice are the most widely used, because compared with these animals, mice have the characteristics of rapid reproduction, small size, docile temperament, and are very easy to raise and breed.

Moreover, among the animals that are easier to raise, mice are relatively close to humans, which can meet most of the experimental needs; in addition, the mouse cell culture system, disease models, operating specifications, experimental standards, etc. are among the most popular among all animals. They are the most mature, even more mature than humans themselves.

Tang Lou looked carefully at the content about mice, and his face turned pale with shock. He seemed to have found the first source of gold for new drug research and development.

As the most commonly used experimental animals, mice are naturally the experimental animals that are most in demand by major institutions and scientific research units.

The most stable and widely raised in China is a kind of small white mouse: a variant of the wild mouse, which belongs to the kingdom of animals, the phylum of vertebrates, the class of mammals, the order of rodents, and the species of rats.

The source is all from a variety introduced from a research institute in India to Kunming, Yunnan in 1946. It is also known as the Kunming species, Kunming, and is well-known in the medical field.

In the 50s, it was introduced from Kunming to the BJ Institute of Biological Products, and then transported to all parts of the country for breeding.

After people's long-term selection and directional cultivation, many varieties have been formed, and there are more than 250 inbred lines recognized internationally.

The so-called "inbred line" is to mate the cubs of mice with their parents, and then mate with their grandparents and mothers after giving birth to offspring. After more than 20 generations of this cycle, a mouse with a particularly close genetic background can be screened out. Family, this is the concept of inbred line.

Because the genetic background of inbred strains is similar, as long as two mice belong to the same inbred strain, their experimental results will be consistent, which is very important for biological research that requires strict control of variables.

The morphological characteristics of mice of various inbred strains are slightly different, but basically the same, and Tang Lou found that under the experimental animal theory (one star, 3), there is actually a more optimized inbred strain ICR mouse .

The method of breeding this optimized mouse is also very special, that is, to optimize it through the experiment of chromosome aberration in Kunming white mouse.

The optimized ICR mice have good motherhood, particularly docile temperament, strong physique, and rapid growth. It can be said that as long as this mouse is released, it will inevitably cause a major earthquake in the entire animal experiment world.

Moreover, this chromosomal aberration experiment induces chromosomal aberrations in mouse bone marrow cells by administering cyclophosphamide (CP) and colchicine (COL) at different time points and at different concentrations.

The operation process is extremely complicated, as long as there is a slight difference, it cannot be successfully induced, that is, it is irreproducible and original.

Even to some extent, the cultivation and launch of Tang Lou's ICR mouse inbred strain has a huge market and profits that are no lower than those of the launch of high blood pressure drugs.

As long as it's done properly, it's all money!
Of course, the most important thing is that as long as Tang Lou publishes his research, it will definitely cause a huge sensation in the world of animal experiments and gain huge fame and fortune.

However, now Tang Lou is only in his virtual laboratory, what he needs is to start the first batch of cultivation and induction in reality.

Tang Lou exited the system space, returned to reality, and began to think about how to carry out his first step plan.

After all, all theories are false. In reality, laboratories, medicines, and tools all need money to realize.

The entire pharmaceutical process, the synthesis of pre-compounds, Tanglou can also be synthesized and prepared through the laboratory of Zijingang Cardiovascular Disease Research Institute.

However, the following animal experiments are not so simple. This requires detailed experimental data to support, and huge data requires countless experiments, and experiments require a lot of manpower and material resources to complete.

"How to do?"

Tang Lou thought about it, and suddenly thought of Jin Yujin, the boss of Modu Jin's Pharmaceutical, among his WeChat friends.

At that time, Jin Yu said that as long as his project is reliable, he is willing to cooperate with him.

Tang Lou thought for a while, and without hesitation, he sent a WeChat message like Jin Yu, roughly saying that he now has a research and development project for a new drug for high blood pressure, which is still in the preparation process, but has completed the basic research and the preliminary compound synthesis route. The research has even deduced the chemical formula and physical parameters of the core medicament.

Of course, it is impossible for Tang Lou to disclose the specific details to Jin Yu.

Not long after, President Jin wrote back to Tang Lou: "Doctor Tang, this matter is not trivial, if you have time, you can come to our company to discuss it."

Of course, Jin Yu's starting point was just to meet Tang Lou to express his gratitude, and then fulfill his previous cooperation commitment. Of course, the cooperation here was just a formality.

He didn't really think that Tang Lou could complete the basic research of high blood pressure drugs and the compound synthesis route. As for the chemical formula and physical parameters of the core drug, it was even more impossible.

With their company's tens of billions of assets, billions of investment per year, and dozens of projects, it is thankful that one project can progress to chemical formulas and physical parameters.

As for Tang Lou, a young doctor, how long did he work under the name of Professor Liu of Zijingang University, and he deduced the core drug sample of high blood pressure medicine?

But Mr. Jin is not surprised. Every year, so many confident young people come to recommend themselves and strive for their own investment.

Tang Lou thought about it, and of course agreed to go to Shanghai to pay a visit to Mr. Jin. It only takes more than an hour to travel by train from Hangzhou to Shanghai.

When Tang Lou got off the bus at Shanghai Hongqiao Station, a special driver came to pick him up.

More than half an hour later, Tang Lou came to Jin's Pharmaceutical Group.

It has to be said that King's Pharmaceuticals is still a very large pharmaceutical company, and of course it cannot be compared with those top pharmaceutical companies, such as Pfizer, Johnson & Johnson, and Novartis.

King's Pharmaceuticals specially purchased land to build a medical valley, which is full of its industries and various supporting facilities, all of which reveal their wealth and wealth.

From the main entrance to the chairman's office, all the way to the tenement building, I was also filled with emotion. Since the entire park is a pharmaceutical company, the environment is almost abnormally clean and tidy.

Passing through the entire white tone building complex, Tang Lou came to the most central office building.

Jin Yu met Tang Lou in the grand living room.

"Doctor Tang, welcome to our company."

(End of this chapter)