From small clinic to medical empire

Chapter 277 New Drugs and New Technologies

About three hours later, Lao Shen walked out of the small theater of Haoran Medical College in a daze.

The Indian Russell spoke to him enthusiastically, but Old Shendu just nodded mechanically.

It was this mechanical nod that made Russell thank him repeatedly as if he had received some great promise.

By the time Lao Shen reacted, it was already too late.

He didn't even remember what he had promised this Ah San.

But if you want to say that the most distraught among the people who left the venue, this is not Lao Shen.

His neighbor, the middle-aged doctor from Shanghai No. [-] Hospital, left with a complicated expression.

From his figure, one can see three parts of sorrow, three parts of hesitation, three parts of surprise, and one part of joy.

Such complicated feelings naturally did not originate from the opening ceremony of Haoran Medical College, nor did they come entirely from the speeches of five Chinese and foreign visiting professors.

Indeed, whether it was the speech of Academician Wang Bin or the platform of an international leader like Anthony Fauci, the participating scholars were amazed.

But after all, the doctors who can be invited by Haoran Medical are those who have cooperated and communicated with Haoran Medical.

They have a general understanding of Haoran Medical's strength.

Except for Fauci who suddenly appeared, the appearance of several other experts more or less did not exceed everyone's expectations.

What really shocked the participating medical scientists, especially the undercover agents from the Shanghai No. [-] Hospital, was the third part of the conference.

In this session, Kong Xiang, Yuan Qiang and others presented the latest clinical and scientific research results.

You know, only four months have passed since the Shanghai Annual Meeting!

Don’t these Haoran doctors have to work in clinical settings?

Even if you spend all day in the laboratory, you can't do interviews with new results in such a short period of time, right?
This is really a high-yielding sow!
Moreover, after careful analysis of these research contents, it is not difficult to find that their value is also very sufficient, and they have not deviated from the clinical line at all.

For example, Kong Xiang's article "Discussion on Retinal Repair after Orientation Induction Using Subcutaneous Nerve".

This paper, which will be published in the forthcoming fifth issue of "Haoran Internal Journal", is essentially a copycat of Zhang Zifan's previous method of treating brain injury after neuron-directed induction and differentiation.

But don't underestimate the copycats in medicine.

Although they are all neurons, the physiological properties of different cells vary widely, and there has never been a universal method that can solve all problems.

Since Zhang Zifan cured Schumacher, he and his miraculous therapy have been valued by medical workers all over the world.

Scholars who studied Zhang Zifan's method and tried to magically modify it and then apply it to other systems were like a crucian carp crossing the river.

That's what science is all about.

Just like online novels, whenever a certain subject becomes popular, there will be a large number of followers immediately.

For example, for a while, "Shenhao" can fill the screen, "Overcautious" can fill the screen, and "I Really Don't Want XXX" can fill the screen.

It is not a crime to follow the trend, but it is reasonable to learn from it.

But the key point is that there are actually very few people who can really succeed in following the trend, learn the essence, and achieve the ability to attack jade with other stones.

This time, the trend of inducing neuron differentiation is equally mixed.

Ask yourself, the scholars present have more or less heard of colleagues, brothers, and even themselves doing experiments in this area.

But in just four months, most of them have not even completed the first step of the experiment, which is to induce reverse differentiation of mature cells.

As a result, at this time, Haoran Medical's ophthalmology officer jumped out and said that not only had he perfectly reproduced the original experiment in the laboratory, but he had even applied it in clinical treatment and achieved impressive results.

It's like everyone is ready to start copying, oh no, borrowing from a certain fire novel.

I haven’t even figured out the outline here, and the editor rejected it three times at the beginning, but the man next door named Kong actually told you that he has already divided into Qiang, Sanjiang, and Qiang to put it on the shelves. The first order is [-], and the daily sales are all. Standing in the top ten.

What can you do about this kind of thing?
Other than smashing your teeth and swallowing it, forcing a smile to express your blessings, and replying with the sentence "The big guy is awesome, I'm looking for a new one", what else can I do?

This group of medical workers who participated in the meeting were basically in this state.

After all, I have a very good relationship with Haoran Medical. If I have a good licking, I will start a joint discipline or something later. I am the academic master of this hospital and the hero of the discipline.

In contrast, the undercover brother from the Ninth Hospital of Shanghai was just purely depressed.

He thought about how to reply to the leader.

If you tell him, "It's not that the brothers don't work hard, but Haoran's bastards are as high as", I don't know if it will work...

However, before he could think of words, today's Wang Zha finally appeared, completely shattering all his fantasies.

This Wang Zhan is Zhang Zifan, Liu Xiaonan, Campbell, and Li Jiaxian, who took the stage together to do a "school-run enterprise" about Haoran Medical College, and the launch ceremony of Haoran Bio's series of product releases, which is the third phase of clinical trials of new drugs.

Among the people present, only Wang Bin had heard about it.

But all he knew was that the entomology experts under Zhang Zifan had discovered a new type of maggot extract, which had certain antibacterial and blood coagulation functions.

The performance of this drug itself is reliable, and Wang Bin personally came forward to get the audit and certification of its characteristic new Chinese patent medicine preparation.

With the help of a series of preferential policies, the drugs named "Haoran Antibacterial" and "Haoran Xueshuantong" have a high priority in approval, which saves a lot of unnecessary time wasting.

And regardless of whether it is reasonable or not, as Chinese patent medicines with special value, Antibacterial Bao and Xueshuantong have relaxed the time for phase one to four clinical trials in accordance with relevant regulations.

The so-called Phase I experiment is the so-called safety experiment.

The purpose is to test safe doses of new drugs, requiring only a small number of patients to participate.

It should be noted that the few cases here refer not to sick people, but to healthy people.

Before the first phase of the experiment, in fact, there are related animal experiments that have basically confirmed the safety of the drug.

But some factors cannot be found in animals, such as mental factors, it is difficult for animals to express whether it is excited or depressed, but after taking certain medicines, people may also feel anxious, irritable, restless, etc. All the factors can only be realized by human beings.

Therefore, it is necessary to clarify the various adverse reactions of the drug on the human body and the metabolic rate through the first phase of the experiment, so that the research on the drug can proceed downward.

Since the first phase of the experiment only requires the participation of a dozen healthy people, and the time requirements for the investigation of natural Chinese patent medicines are looser than those of chemical drugs, the experiment was completed quickly.

The second phase of the experiment is an experimental study of effectiveness, which requires the participation of hundreds of patients.

This experiment should be done in strict accordance with the principles of random grouping, placebo-controlled, and double-blind experiments.

It is not possible to shorten the time or release water just because it is a natural medicine.

Fortunately, whether it is antibacterial drugs or anticoagulant drugs, the effect is relatively clear.

Unlike antihypertensive drugs and anticancer drugs, which require multi-dimensional, multi-indication, and long-term verification.

Therefore, after a small-scale recruitment of volunteers, Haoran finally completed the second phase of the experiment until last week.

Although ordinary people usually hear that it is more likely to be phase III or phase IV clinical trials.

For example, a certain multinational pharmaceutical giant announced that a certain drug had a major hidden danger and announced the recall of related products.

For example, how many cases of adverse reactions caused by a certain drug in the world, and what experts suggest.

For example, a certain terminally ill patient voluntarily tries a certain drug, and finally survives from desperation.

These are actually in the category of Phase III and Phase IV clinical trials.

For the public, these late-stage clinical trials seem to be more important, but in fact, the second-phase clinical trials are the most important thing for the success of a drug.

The earliest animal experiments were a big filter for drug development.

The Phase [-] experiment is the second.

Its success rate often does not exceed 30%.

Seventy percent of new drugs will be eliminated, and the huge amount of research funds invested in the early stage will be in vain.

The drugs that have passed the big filter of the Phase II experiment have actually proven their effectiveness and preliminary safety, and are generally closer to success.

The third phase of the experiment is basically a continuation of the second phase of the experiment. It also strictly abides by the principles of random grouping, placebo control, and double-blind experiments, but the number of people participating in the experiment will reach thousands of people.

Due to the large number of experimenters required, it is impossible to find enough experimenters only by small-scale mobilization.

Therefore, phase III experiments often solicit volunteers from the whole society through hospitals.

Sometimes when you go to the hospital for medical treatment, the doctor may introduce you to similar experiments.

Generally speaking, the safety of drugs that have passed the second phase of the experiment is already relatively high.

At the same time, the bonus for participating in the experiment is quite considerable.

Many patients are still willing to give it a try.

As for the Phase [-] trial, as mentioned above, that is after the drug is launched on the market.

At this time, the drug inspection department will also require the research and development units and medical institutions to continue to make relevant statistics to further prove the side effects and therapeutic effects of this medicine in large populations, and what adjustments to make in dosage.

The cycle of this four-phase experiment will be quite long.

After understanding the respective functions of the first to fourth phases of drug trials, we also understand why everyone was surprised when Zhang Zifan announced that two new drugs had entered the third phase of the trial and recruited volunteers from the whole society.

Because of the quietness, this Dean Zhang actually set up a biological company while starting a college, and the two new drugs have already succeeded by more than half.

For such an operation, most medical workers who have spent their entire lives in this professional field don't know what to say.

If you want to say that Dean Zhang is not doing his job properly...

It is hard to imagine that this medical college with less than [-] people will not be able to run a school where the five heavenly kings stand on the platform at the same time.

To start a business, two new drugs are about to come out.

Everyone knows the situation of new domestic drugs.

As long as it can be successful, it does not seek to be better than similar foreign drugs, as long as it is not too bad, it is a real hen that can lay eggs.

You know, it is said that the boss of a Chinese patent medicine company spent 4000 million yuan to send his daughter to study in the United States.

All of a sudden, everyone looked at Zhang Zifan with reddened eyes.

But as the saying goes, good things come in pairs, and Wang Bo is in pairs.

Zhang Zifan quickly asked Campbell to announce the last and most important news in the audience in awkward Chinese.

That is, the new technology of assisted reproduction, which does not go through the stage of embryonic stem cells, and the autonomous meiosis of somatic cells to form germ cells, has been successfully developed and put on trial in the Assisted Reproductive Center of Haoran Hospital.

This awkward name, combined with Campbell's awkward Chinese, made everyone who was still immersed in guessing Zhang Zifan's future worth not realize what was going on for a while.

It was not until Campbell opened the carefully prepared PPT that the audience was in an uproar.

Dean Zhang plans to rely on two new medicines to make a living?
We are still too naive.

What we think of as just rice is just a small appetizer before the meal.

Compared with the huge market of assisted reproduction, two Chinese patent medicines are nothing!

At this time, everyone in the audience couldn't help but have such thoughts in their minds.

However, they didn't know what kind of curative effect the two new drugs derived from the secretion of human skin flies had in Zhang Zifan's hands.

To be honest, due to some reasons, among the new Chinese patent medicines, the proportion of crudely manufactured medicines is still very high.

After all, classic prescriptions such as Yunnan Baiyao have already been developed.

Latecomers can only find new breakthroughs from the pile of old papers.

There are both rigorous scientific workers and great achievements.

For example, Ms. Tu found clues in various and even contradictory ancient books, tried hundreds of possible "artemisia annua" herbs, and finally extracted artemisinin from Artemisia annua to benefit all mankind.

But there are also absurd things such as inter-provincial warnings and inadequate books.

In short, because of some black apples, Chinese patent medicines are good and bad, and their reputation is somewhat problematic.

Therefore, everyone preconceived that the new medicine in Zhang Zifan's hands was nothing more than that.

If they knew that Zhang Zifan’s Haoran Antibacterial has the potential to inhibit or even kill superbugs, Haoran Xueshuantong can also replace aspirin and warwarin and become a safer blood vessel anticoagulant drug, they would not be so sure. The gold-absorbing ability of these two drugs must be weaker than artificial assisted reproductive technology.

As the so-called layman watches the fun, the expert watches the doorway.

Medical workers who have been involved in cell experiments vaguely saw the shadow of cloning technology in Campbell's PPT.

But this is completely different from traditional cloning technology.

Through meiosis, the new technology completely restores the process of natural reproduction.

When a thing looks like a sperm, its cell components are like a sperm, its genetic information is like a sperm, its function is like a sperm, its formation process is like a sperm...

So why can't it be considered that it is a sperm?

Furthermore, what it forms is naturally a real fertilized egg, a real life.

This is definitely not cloning, nor copying, but rebirth!

Everyone is feeling the application prospect of this technology.

But old Anderson narrowed his eyes.

This middle-aged speaker, Campbell, with restrained radiance, seems a bit familiar.

In old Anderson's mind, the sheep that was popular all over the UK many years ago, the knight standing beside it, and the unknown young man in the corner gradually came to mind.

It seems that someone may be unlucky...

Old Anderson stroked his beard, and once again praised his foresight.

…………

Thanks to the students who do not make money by raising fish for rewarding 1000 starting coins

Thanks to Doll q for rewarding 500 starting coins

Thank you Huzishitou students for rewarding 100 starting coins

(End of this chapter)