I can extract side effects.

Chapter 629 Organ Transplantation for Baboons
"25 minutes!"

"The transplanted kidney produced urine within 25 minutes of reperfusion with blood."

The chief surgeon stared at the baboon's urine bag, his eyes shot out, and he shouted excitedly.

For a moment, everyone turned their attention to the past.

The originally empty urine bag was now half filled with orange liquid.

This somewhat disgusting liquid seemed to ordinary people, but in the eyes of everyone present, it was so pleasing to the eye, even more charming than the most beautiful flowers.

Everyone stared at the urine bag, all showing fascinated smiles.

"Hahaha, it finally succeeded." Du Biao rubbed his chin, feeling relieved.

"There was no acute rejection for half an hour, indicating that the immunosuppression was very successful. It depends on how long you can live after transplantation."

Huang Qin also breathed a sigh of relief, feeling that he was one step closer to the final success.

"For xenogeneic organ transplantation, the international consensus has been established to enter clinical trials. After testing on non-human primates, they survived for more than 6 months, and the continuous success rate reached 60%."

Dean Liu has done relevant homework and is familiar with various standards, he said cheerfully.

"Didn't you prepare 6 pigs? As long as 4 can survive for more than half a year, they can reach the clinical standard."

"There are 2 of them with a fault tolerance rate, and the probability is still quite high."

The chief surgeon also nodded in agreement: "For xenotransplantation, the kidney is the most ideal organ. You have chosen to start with the kidney, and you are doing the right thing."

"Because unlike the heart, if there is a problem, the kidney can be removed and the patient can receive dialysis."

"There is only one heart. If something goes wrong, I'm afraid it cannot be saved."

"In addition, the success rate of islet transplantation is also very high. At present, the immune system of baboons has not rejected the pig's organs, nor has there been a large amount of bleeding after transplantation. It can be seen that all functions are normal."

"It will be fully tested later to see if the transplanted organ is damaged in the short term, and the insulin levels in the baboons will be checked."

"In the next few days, we will closely monitor this baboon and pay attention to its survival time. All test results will be notified to you as soon as possible."

"However, the absence of acute rejection, which is a good thing, does not necessarily mean that chronic rejection cannot occur."

In the end, the surgeon in charge expressed a degree of concern.

"What is not known is whether the baboon's immune system will attack the transplanted organ after a few months, and it is also unknown whether the organ will continue to function by then."

Huang Qin said thoughtfully: "You are very reasonable. I hope the baboons can survive longer."

"There are ready-made examples of islets abroad. After transplanting gene-knockout pig islets, monkeys survived for a year and improved their diabetes."

"So I'm not worried about this, I just hope that the complications of kidney transplantation can be reduced."

"Hahaha~" Du Biao laughed from the sidelines: "The success of the operation is already a happy event. As for how long we should survive, it is not something we should think about now. We just need to wait and see."

"If I remember correctly, this is the first multi-organ xenotransplantation in China."

"This is big news that broke the record. We have to celebrate and publicize our achievements."

"That's right, teacher, I'll leave this part to you. Call the reporters later and make a good publicity."

Huang Qin nodded, and then told the eight students who were silent behind him.

"You have taken turns staying here for the past few days, carefully observing the condition of the baboons after the operation, and recording them one by one. The more detailed the better."

"understood!"

The students responded in unison, their immature faces full of uncontrollable joy.

Fortunately, they also knew that this was not a laboratory, but a serious operating room, so none of them jumped up cheering.

The success of this transplant operation shows that the genetic modification of pigs is very successful.

As long as the baboons survived and the postoperative conditions were recorded, it would be a perfect end to this experiment.

If it survives for more than 6 months, it will not only break the record, but directly create a miracle.

Students who are only in their 20s have limited life experience, so they have never seen such a big scene before.

At this moment, all of them felt like they had been injected with ten catties of chicken blood, their hearts were pounding and their adrenaline was being secreted crazily.

As soon as he heard the senior brother's order, he immediately agreed like a robot.

After Du Biao and Huang Qin left together, they took turns guarding the operating room and the breeding room to observe the xenotransplanted baboons.

******
"On the first day after the operation, both kidneys urinated about 1ml."

"The baboons' serum creatinine began to slowly decline, the creatinine was excreted in the urine by the kidneys, and the transplanted kidneys began to function."

"On the third day after the operation, the fasting blood sugar level of the baboons decreased significantly, and the secretion of endogenous insulin was detected in the body, which greatly enhanced blood sugar control."

"On the 5th postoperative day, a biopsy was performed on the left kidney, and the renal tubules and glomeruli were normal."

"There was no endothelial injury, fibrin thrombus, and no evidence of immune rejection."

"Daily blood sample analysis showed that all porcine endogenous viruses were negative."

"That is to say, no undesired porcine virus derivatives were detected in the baboon blood."

"At the same time, as there were no signs of immune rejection, the dose of immunosuppressants was gradually reduced."

"So far, the baboons who received xenotransplantation have survived healthy and healthy for 7 days."

"Although chronic immune rejection cannot be ruled out, there should be no problem for this baboon to survive in a short period of time."

Huang Qin read the report on the computer line by line, stared at the picture of the lively baboons on the screen for a long time, and then burst out laughing.

"Teacher, it seems that our xenotransplantation experiment is really successful."

"When doing scientific research, you must remember to guard against arrogance and impetuosity. This is the first step. If a baboon can live for 7 days, it is nothing. If it can live for 70 days, it will be fine. If it can live for 700 days, it will be considered as the real goal."

Standing behind him, Du Biao looked at the data on the screen and was immediately relieved.

He originally wanted to warn him habitually, but when he saw the senior disciple smiling so happily, he just reminded him a little, and then laughed happily together.

"But this time everyone really did a good job, and my old face is also stained."

"If the baboons are still alive in two months, you can write your own paper and publish it in "Nature" or "Life". There should be no problem."

Thinking of this, Du Biao suddenly became excited. This is the top journal. He finally has a top journal paper under his name. Who would dare to call him Professor Buffalo in the future?
As long as this paper is published, he will be able to slap a wave of face severely, and beat back all the clamoring voices of those trolls on the Internet.

Besides, if there are no top-published papers, how can you judge outstanding young students?
When he, as the corresponding author, is on the cover of the top magazine, there will be no suspense in this year's outstanding youth selection.

The more Du Biao thought about it, the more excited he became, he couldn't close his mouth from ear to ear, and the nasolabial folds on his face stretched a lot.

"That's right, during this period of time, I will write a first draft first, wait for the later data to come out, and then put it in together, refine it and publish it."

Huang Qin said casually, his hands were crackling, and he had created a new word document.

"Report on Early Organ Transplantation of Kidney and Pancreatic Islets of 36 Genetically Modified Pigs"

Corresponding author: Du Biao
Author: Huang Qin
He paused, and quickly added the names of eight other students after his own.

Du Biao looked at this scene and nodded secretly in his heart. Xiao Huang is really good. For such a heavy paper, no matter how close or distant the students are, no matter how high or low the students contributed, everyone has a share.

As the only student who successfully bred genetic pig embryos, Xiao Gao was awarded the status of the second author.

Although the second author's gold content is not as good as the first author's, but the recognition is still relatively high, especially the top-published papers, which are of great significance to him.

Not only can it be awarded, but it can also be counted as his research results.

Considering the prospects of the field of xenotransplantation, he has a high degree of participation in the project, and he is likely to become a unique talent after graduation.

As for other students, even if the embryo cultivation failed, they did not make any important contributions to the project.

But there is hard work without credit, and it is also due to obtain the authorship of three, four, and nine papers.

It's just that the degree of contribution is definitely not as high as the previous ones, and the recognition obtained is relatively limited.

But considering that among these students, the worst has published five SCI/CSCD papers, which has fully met the graduation requirements for graduate students.

Du Biao couldn't help thinking about another practical problem.

He pondered for a moment, then spoke after deliberating.

"Little Huang, when your paper is published, it should be time for Research 3."

"That's right." Huang Qin said casually while writing down his thoughts.

"Then have you considered graduating early?"

"Huh?" Huang Qin suddenly turned his head, looked at the instructor, and widened his eyes.

Du Biao thought he didn't understand, so he explained in detail.

"You see that you have completed all the courses in the first year of research, and your grades are very good."

"The research direction is determined after half a year of research, and the graduation assessment requirements have been completed after the first draft of the thesis is completed in the second research."

"In the second half of this year, that is, when I am in the third year of research, I will publish my thesis and finish my graduation thesis defense at the end of the year."

"You can graduate right away."

Having said that, he couldn't help feeling emotional.

"Two and a half years, you will be able to graduate directly with a Ph. D. I have never brought such a student in my life."

"You have published a paper before others have determined the research direction, you have completed your graduation defense while others are still learning to do experiments, and you have produced world-wide research results when others are still worrying about opening a thesis topic."

"Xiao Gao and the others call you Senior Brother, you really deserve this title."

"From now on, you will be the big brother of our department. When the juniors and juniors step into work, you should take care of them more."

Hearing what the teacher said, Huang Qin asked in surprise.

"Well, haven't I been a direct blogger for five years?"

"Can you graduate so early?"

"Is there no minimum graduation year?"

Du Biao said angrily: "Everyone's doctorate is delayed, and those who can graduate early are already excellent students."

"Others graduated a year and a half earlier, so there is no one like you."

"But there is no other way. Who told you that you are too capable? A doctorate is not a work contract. You have to work for five years, and you can graduate if you meet the graduation requirements."

"I'm not the kind of tutor who squeezes students, how could I block you from graduating?"

"Actually, getting a Ph.D. in two and a half years is not in compliance with the regulations. It takes at least four years for a direct Ph. D., but you are not an ordinary person."

"You can replace me as a doctoral supervisor, why are you still pretending to be a student in school? Is it fun?"

"If you really don't want to graduate, that's fine, that's up to you, just stay on campus as a good student for two more years."

Hearing these words, Huang Qin raised his eyebrows and nodded repeatedly.

"I was wrong. The teacher taught me well and gave me enough respect and freedom. Only then did I have room to develop freely and graduate early."

"Don't worry, I will definitely protect the younger brothers and younger sisters after they graduate."

"If you want to work in Sanqing, you can do it. If you want to go to other laboratories, I will strongly recommend it."

Du Biao thought for a while and added.

"Actually, although you graduated in two and a half years, you just completed the thesis defense. You have to wait a few months to get your degree certificate and graduation certificate. It is estimated that it will take almost three years."

"The main thing is that you have written several doctoral dissertations before and now, and your scientific research level is already at the level of a doctor."

"In this way, the biggest problem of obtaining a doctoral title, the requirement for a thesis, is easily solved. So it's not an exception for you alone."

"I remember that there is a Nobel laureate named Axelrod abroad. He has worked for many years and achieved fruitful results, but in order to start a new business, he must obtain a doctor of science title."

"So he went to study for a Ph.D. at the age of 42, just like you, studying while working."

"However, he studied for a master's degree when he was working before, and he also published many doctoral-level theses, so it only took him one year to complete his doctoral studies."

"If you calculate it like this, it's about the same as him. It takes 2 years to graduate with a master's degree and 1 year to graduate with a Ph.D. Overall, it's very reasonable."

Huang Qin was stunned when he heard this: "Why do scientists still need a doctoral title when they set up a new school?"

Du Biao coughed lightly and gave him a meaningful look.

"Since you asked, let me tell you that this is almost the default rule in academia."

"For scientific research institutions, one must have a doctorate title to become the head of the laboratory."

"The job titles of colleges and universities are similar. For example, if you want to be a professor, a doctoral supervisor, or a young scholar, you must have a final degree, that is, a doctorate."

"Of course, there is no such requirement for the industry. If the company is willing to hire a master or undergraduate as the person in charge of R&D, that is also the boss's own business."

Hearing this, Huang Qin couldn't help blurting out: "Why isn't this education discrimination?"

As soon as the words fell, he laughed awkwardly: "Teacher, I said the wrong thing."

Du Biao chuckled: "You are also a doctor now, but I don't want to say that."

"In short, for those who pursue academic pursuits like you, it is better to study for a Ph.D."

"Sanqing has won such a good direct blogging condition for you, and I think it is to encourage you to learn and improve."

"Understood, understood, I just said that casually."

Huang Qin chuckled, feeling a little more grateful to Xue Shen in his heart.

If it wasn't for Xue Shen's unintentional remark back then, which aroused his motivation to make progress, he really would never have thought of coming to study for a Ph.D.

Even such a promising xenotransplantation project was helped by Xue Shen.

"I have to treat Lao Xue to a big meal later, and thank him well." He secretly made up his mind.

"In the future, if he gets terminally ill and needs an organ transplant or something, I will definitely give him a complete set as soon as possible."

"What pig heart, pig lung, pig liver and pig kidney, a whole set will be arranged for him, and he can transplant whichever he wants to transplant."

(End of this chapter)