I can extract side effects.
Chapter 573 Exploring the Mystery of the Human Brain
Chapter 573 Exploring the Mystery of the Human Brain
The success of the animal experiments instantly inspired everyone's fighting spirit.
Everyone seems to have been injected with chicken blood, devoting themselves to work day and night.
Everyone knows that animal experiments are only the first step, and the next human test is the biggest challenge.
The first human test, that is, the feasibility test, is very important to the project and determines whether it can obtain a pass for subsequent clinical trials.
Work cannot proceed until the safety and effectiveness of the device has been proven.
Fortunately, the technology of cerebrovascular stenting is very mature, and the related interventional surgery has a history of nearly 50 years. Generally speaking, the safety is quite guaranteed.
It only needs to make some improvements on the alloy material to make it a microelectrode that can collect nerve signals.
As for the neural chip implanted under the skin, the size is very small, and it is wrapped in biological protein materials, which is also highly biocompatible and safe.
So, after providing real-time recording and neural data transmission results within a month, the application for the first human test was approved.
Upon hearing the good news, Chen Yiqing immediately held a project meeting.
He stood in the meeting room, his face full of uncontrollable excitement, and while speaking, he waved his hands violently, as if to strengthen his opinion.
"Everyone, from animal experiments to human testing, the brain-computer interface system is about to take a critical step."
"The first human test is the most important thing, which determines the life and death of the project. We must go all out and make perfect preparations."
"While the device demonstrated excellent performance and data quality in monkeys, human testing, obviously, is another matter."
"From the design to the execution of the whole experiment, every step cannot be taken lightly. We need to design some new processes and algorithms, and increase engineering components and computers. All these devices will be combined to operate in real time and without errors. We collected Only the data can be used.”
"Also, this is our first human test, and it is difficult to predict what will go wrong in the experiment and what kind of results will be produced."
Having said that, he looked over one by one, and said slowly: "Everyone, please."
Wang Dali was the first to speak. He waved his fist and yelled excitedly: "Hahaha, I have finally reached the stage of human body testing. I have already had a lot of new ideas in my mind, and I can't wait to realize them."
"Come on, if you have something to say, I'm so sleepy, I have to go back to the office to catch up on sleep." Wen Renlong rubbed his eyelids, covered his mouth and yawned, and said lazily.
During this period of time, he swept away his previous lazy style, squatting in the laboratory day and night, and it can be said that he devoted himself to it.
Not long after falling asleep this morning, he was arrested for a meeting, and he didn't even get enough sleep. At this moment, he was exhausted and drowsy, and even the dark circles under his eyes were a little more obvious than usual.
Chen Yiqing glanced at Wen Renlong apologetically, and said, "I'm sorry, I'll finish speaking quickly, and I won't waste your time."
"Okay, the next important issue is the selection of subjects."
Wang Dali interrupted suddenly: "Aren't you looking for a paralyzed patient? Do you remember that Zhu Jun? He has been contacting me recently, and his attitude is quite firm. I think he is good."
Chen Yiqing glanced at him, hesitated to speak, and said after a while: "For the first human test, I hope to obtain more comprehensive neural data. It will be better if it is a healthy person."
Wang Dali said in surprise: "However, who in a healthy person would accept stuffing things into their brains? It's not just a matter of taking medicine for a few days. Although the operation is very safe, the risk is still very high. This kind of thing doesn't even cost money." Let's do it."
Chen Yiqing shook his head and pointed to himself: "You don't need to find someone else, I will do it myself."
"What?" The others stood up together and looked at him in shock.
"Chen Bo, this is not acceptable. You are the person in charge of the project, and you are the one to study others. How can you study yourself?" Wang Dali said very seriously, "You should consider going to the patient directly."
"Have you ever thought that we haven't done tests on humans yet, we haven't collected enough neural data to build a human motion model, and paralyzed patients can't move their limbs, and the accuracy of the data provided can't be compared to normal at all. comparable to people."
Chen Yiqing said in a deep voice: "In other words, if we use normal people, we can get a correct answer directly, but if we use patients, we may get a wrong answer at the beginning, and it will take a long time to correct the error. "
Wang Dali is still trying to persuade him to give up this idea: "Of course I know this, but the risk is too great, you don't need to use yourself as an experiment."
Even Wen Renlong couldn't help but say, "Old Chen, you can just spend a little more money to hire someone. As long as we finish the experiment and take out the equipment, someone will definitely be willing."
Wang Dali nodded quickly: "That's right, I can improve it and make a version of the experimental stent, the kind that can be removed, and Dr. Jian is there for cerebrovascular interventional surgery, so there is almost no risk. volunteer."
Jian Lianyun originally wanted to say something, but when he looked at Chen Yiqing's firm eyes, he knew that the other party's mind was determined, and it was difficult to be persuaded, so he couldn't help but keep silent.
Zhang Li was the only one sitting on the chair, and her expression remained unchanged, as if she had expected it.
Chen Yiqing couldn't help smiling when he saw the big reaction from the crowd, and said, "Believe me, I have carefully considered every reason you mentioned."
"As a researcher, I have reasons for doing so. Besides, the law does not prohibit scientists from conducting experiments on themselves."
"This..." Everyone looked at each other, not knowing what to say for a while.
Chen Yiqing smiled lightly: "In this case..."
Suddenly, a voice interrupted his words.
"Let me do it." Zhang Li stood up and said firmly, word by word.
"Chen Bo, I am also a scientist, and I am younger and have better physical fitness than you. I am a more suitable test subject."
Wang Dali was taken aback: "No way, are you neuroscientists so upright?"
He couldn't help giving a thumbs up: "That's right, he's a ruthless person, he always tries to do experiments in his own mind, and even rushes to come here, one is really more ruthless than the other, I really admire, admire!"
"Lily, no, you absolutely can't." Wen Renlong suddenly became very agitated, and stepped forward to grab Zhang Li's arm: "Don't be impulsive, we can discuss this matter later, no matter how much money you spend."
Zhang Li flicked her arm, but she didn't shake it, so she had no choice but to say angrily: "Brother, can you stop doing it? If you have something to say, speak slowly."
"No, I won't let you go if you don't agree." Wen Renlong shook his head like a rattle, and his tone was very firm.
Zhang Li gave him a blank look: "Brother, who are you, you are really lenient."
Jian Lianyun was also stunned. She looked at Chen Yiqing and then at Zhang Li. Their attitudes were equal, and they were both equally determined.
She thought about it, and for some reason, she thought about which one was more suitable for cerebrovascular surgery.
From the surgeon's point of view, Chen Yiqing is 45 years old, and his physical function has begun to decline. The possibility of blood clots and hardening of blood vessels is increasing. The risk of surgery is much higher than that of Zhang Li, who is in her 20s.
"Hey, what am I thinking about? What time is it? I'm still thinking about surgery, so I need to persuade these two people to stop thinking about it."
Jian Lianyun suddenly came to his senses, and when he looked up, he saw four people talking to each other, expressing fierce opinions.
"This..." Seeing this situation, she didn't like to quarrel, so she shrank her head and stopped talking.
Suddenly, there were two bangs.
Chen Yiqing patted the table and said loudly: "Stop arguing, yes, it's the two of you."
"Anyway, Lily and I have to choose one. If it doesn't work, let's vote."
Wen Renlong was like a duck being strangled by the neck, suddenly lost his voice, and sat back silently.
"Very good. Voting begins." Chen Yiqing looked around, nodded with satisfaction, and said, "Those who agree with me being the test subject, raise your hand."
The venue was silent, no one raised their hands.
After a while, Wen Renlong raised his right hand slowly, and as soon as he raised it above his head, Zhang Li gave him a hard look, which made him put his hand down quickly in fright.
Chen Yiqing raised his left hand, while his right hand made a note: "One."
"Wang Dali, Doctor Jian, you two can't abstain, you have to show it."
Wang Dali said with a dry smile: "This is too sudden, I'm still thinking about it."
Chen Yiqing looked at him, smiled slightly, and said, "Since I only have my vote, the four of you left must be on Lily's side."
"Very good, there is no need to vote anymore, the voting is over, I have one vote, Lily has four votes, and she is the only test subject."
"What?" The others looked at him in shock, unable to react for a while.
"It's just messing around. You're messing around like this. I don't agree." A few seconds later, Wen Renlong was the first to jump out to object.
"Objection is invalid! I am the person in charge of the project, and I have the final decision." Chen Yiqing suppressed him extremely forcefully.
"Okay, it's decided like this. The human body test will start in the afternoon. Lily, make preparations." Chen Yiqing looked at Zhang Li and ordered with a smile.
When Wen Renlong saw the sly look in Chen Yiqing's eyes, he reacted instantly and became furious.
"The two of you are together, and you are making fun of me."
Wang Dali patted his head, and suddenly realized: "Chen Bo, in fact, you have wanted Lili to be the test subject for a long time, and you were afraid that we would disagree, so you came here like this, tsk tsk, this skill is really good, the knowledge of opening windows You figured it out."
"I originally wanted to abstain from both of you, but in the end, you saw through me." He sighed with regret.
"Hehe, I was afraid that you would abstain, that's why I did it." Chen Yiqing chuckled.
"Anyway, your performance just now has revealed your inner thoughts. Between me and Lily, you are more willing to choose her. That's why you didn't raise your hands when facing me. This subconscious expression is actually more real."
Wang Dali was silent for a moment. He had to admit that the other party was right. If he really had no choice, he could only vote for Lily. The reason was very simple, and it had nothing to do with age, just because Chen Yiqing was the project leader.
Jian Lianyun on the side was stunned and speechless. She had really thought about it seriously. She had to choose someone. She could only vote for Zhang Li. After all, she was young and an assistant, so he was not that important in the project.
Wen Renlong stopped talking, he could tell that among the five people present, he was the only one who really opposed it, so no matter how much he protested, it would be meaningless and he could only accept this reality.
"Then after the experiment is over, can the equipment be taken out? Lily can't keep this thing in her mind."
He asked one last question.
Chen Yiqing pondered for a moment and gave an affirmative answer.
"Don't worry, the connecting wire and the nerve chip can be taken out. As for the stent, it may grow together with the blood vessel wall after a long time. It is very difficult to take it out, but the mesh is very sparse. The diameter of the large vein we implanted is relatively large. The overall risk is controllable."
"That's the only way to go." Wen Renlong sighed and accepted the result helplessly.
He looked at Zhang Li, as if he was meeting her for the first time, and began to look at her carefully.
That oval face, which is not glamorous, but quite attractive, has no apprehension or worry, but only excitement and anticipation. The whole face is like white jade, glowing with a strange intertwined youth and knowledge. beauty.
Wen Renlong looked and looked, but for some reason, he couldn't look away for a long time.
"This woman is beautiful, but she's really ruthless." He trembled all over, and this idea suddenly came to his mind.
******
Interventional brain surgery for humans is naturally different from monkeys. It cannot be done in a laboratory, but can only be done in a qualified hospital.
Fortunately, the No.1 Minority Hospital in Kunming is a senior partner of Sanqing, and Jian Yun is the second in command of the department. The brain-computer interface belongs to the joint innovative scientific research project of the two parties. The hospital attaches great importance to it and sent the most sophisticated surgical team.
The surgery was minimally invasive and went well.
It only took half a day from anesthesia to suturing, closing the eyes and opening them again.
Zhang Li was able to get out of bed and walk around that night, but just to be cautious, she was kept in the ward for another three days for observation.
Three days later, when she was discharged from the hospital, the 2 mm wide incision on the back of her neck was almost healed.
During this time, everyone was busy installing large hardware facilities, designing new computer programs, and fixing various minor problems.
And just like that, it was time for the first human test.
In the laboratory, Zhang Li sat quietly on a chair as usual, with a joystick, a flat-screen LCD monitor, and a juice supply machine in front of her.
The same video game also starts with whack-a-mole, and even the actions are exactly the same.
She only needs to move her arm, grab the joystick, control the moving stick on the screen, and hit every gopher violently, and she can enjoy the juice to her heart's content.
As long as a crit action is completed, the juice machine will spout a small glass of her favorite orange juice.
Not far behind, there are rows of computers and monitors on the workbench.
Her brain activity will be recorded and wirelessly transmitted to a computer for further study.
According to the new algorithm, it is converted into a digital electrical signal and sent to the next-door robotic arm to complete a whole set of the same process.
everything's ready.
(End of this chapter)
The success of the animal experiments instantly inspired everyone's fighting spirit.
Everyone seems to have been injected with chicken blood, devoting themselves to work day and night.
Everyone knows that animal experiments are only the first step, and the next human test is the biggest challenge.
The first human test, that is, the feasibility test, is very important to the project and determines whether it can obtain a pass for subsequent clinical trials.
Work cannot proceed until the safety and effectiveness of the device has been proven.
Fortunately, the technology of cerebrovascular stenting is very mature, and the related interventional surgery has a history of nearly 50 years. Generally speaking, the safety is quite guaranteed.
It only needs to make some improvements on the alloy material to make it a microelectrode that can collect nerve signals.
As for the neural chip implanted under the skin, the size is very small, and it is wrapped in biological protein materials, which is also highly biocompatible and safe.
So, after providing real-time recording and neural data transmission results within a month, the application for the first human test was approved.
Upon hearing the good news, Chen Yiqing immediately held a project meeting.
He stood in the meeting room, his face full of uncontrollable excitement, and while speaking, he waved his hands violently, as if to strengthen his opinion.
"Everyone, from animal experiments to human testing, the brain-computer interface system is about to take a critical step."
"The first human test is the most important thing, which determines the life and death of the project. We must go all out and make perfect preparations."
"While the device demonstrated excellent performance and data quality in monkeys, human testing, obviously, is another matter."
"From the design to the execution of the whole experiment, every step cannot be taken lightly. We need to design some new processes and algorithms, and increase engineering components and computers. All these devices will be combined to operate in real time and without errors. We collected Only the data can be used.”
"Also, this is our first human test, and it is difficult to predict what will go wrong in the experiment and what kind of results will be produced."
Having said that, he looked over one by one, and said slowly: "Everyone, please."
Wang Dali was the first to speak. He waved his fist and yelled excitedly: "Hahaha, I have finally reached the stage of human body testing. I have already had a lot of new ideas in my mind, and I can't wait to realize them."
"Come on, if you have something to say, I'm so sleepy, I have to go back to the office to catch up on sleep." Wen Renlong rubbed his eyelids, covered his mouth and yawned, and said lazily.
During this period of time, he swept away his previous lazy style, squatting in the laboratory day and night, and it can be said that he devoted himself to it.
Not long after falling asleep this morning, he was arrested for a meeting, and he didn't even get enough sleep. At this moment, he was exhausted and drowsy, and even the dark circles under his eyes were a little more obvious than usual.
Chen Yiqing glanced at Wen Renlong apologetically, and said, "I'm sorry, I'll finish speaking quickly, and I won't waste your time."
"Okay, the next important issue is the selection of subjects."
Wang Dali interrupted suddenly: "Aren't you looking for a paralyzed patient? Do you remember that Zhu Jun? He has been contacting me recently, and his attitude is quite firm. I think he is good."
Chen Yiqing glanced at him, hesitated to speak, and said after a while: "For the first human test, I hope to obtain more comprehensive neural data. It will be better if it is a healthy person."
Wang Dali said in surprise: "However, who in a healthy person would accept stuffing things into their brains? It's not just a matter of taking medicine for a few days. Although the operation is very safe, the risk is still very high. This kind of thing doesn't even cost money." Let's do it."
Chen Yiqing shook his head and pointed to himself: "You don't need to find someone else, I will do it myself."
"What?" The others stood up together and looked at him in shock.
"Chen Bo, this is not acceptable. You are the person in charge of the project, and you are the one to study others. How can you study yourself?" Wang Dali said very seriously, "You should consider going to the patient directly."
"Have you ever thought that we haven't done tests on humans yet, we haven't collected enough neural data to build a human motion model, and paralyzed patients can't move their limbs, and the accuracy of the data provided can't be compared to normal at all. comparable to people."
Chen Yiqing said in a deep voice: "In other words, if we use normal people, we can get a correct answer directly, but if we use patients, we may get a wrong answer at the beginning, and it will take a long time to correct the error. "
Wang Dali is still trying to persuade him to give up this idea: "Of course I know this, but the risk is too great, you don't need to use yourself as an experiment."
Even Wen Renlong couldn't help but say, "Old Chen, you can just spend a little more money to hire someone. As long as we finish the experiment and take out the equipment, someone will definitely be willing."
Wang Dali nodded quickly: "That's right, I can improve it and make a version of the experimental stent, the kind that can be removed, and Dr. Jian is there for cerebrovascular interventional surgery, so there is almost no risk. volunteer."
Jian Lianyun originally wanted to say something, but when he looked at Chen Yiqing's firm eyes, he knew that the other party's mind was determined, and it was difficult to be persuaded, so he couldn't help but keep silent.
Zhang Li was the only one sitting on the chair, and her expression remained unchanged, as if she had expected it.
Chen Yiqing couldn't help smiling when he saw the big reaction from the crowd, and said, "Believe me, I have carefully considered every reason you mentioned."
"As a researcher, I have reasons for doing so. Besides, the law does not prohibit scientists from conducting experiments on themselves."
"This..." Everyone looked at each other, not knowing what to say for a while.
Chen Yiqing smiled lightly: "In this case..."
Suddenly, a voice interrupted his words.
"Let me do it." Zhang Li stood up and said firmly, word by word.
"Chen Bo, I am also a scientist, and I am younger and have better physical fitness than you. I am a more suitable test subject."
Wang Dali was taken aback: "No way, are you neuroscientists so upright?"
He couldn't help giving a thumbs up: "That's right, he's a ruthless person, he always tries to do experiments in his own mind, and even rushes to come here, one is really more ruthless than the other, I really admire, admire!"
"Lily, no, you absolutely can't." Wen Renlong suddenly became very agitated, and stepped forward to grab Zhang Li's arm: "Don't be impulsive, we can discuss this matter later, no matter how much money you spend."
Zhang Li flicked her arm, but she didn't shake it, so she had no choice but to say angrily: "Brother, can you stop doing it? If you have something to say, speak slowly."
"No, I won't let you go if you don't agree." Wen Renlong shook his head like a rattle, and his tone was very firm.
Zhang Li gave him a blank look: "Brother, who are you, you are really lenient."
Jian Lianyun was also stunned. She looked at Chen Yiqing and then at Zhang Li. Their attitudes were equal, and they were both equally determined.
She thought about it, and for some reason, she thought about which one was more suitable for cerebrovascular surgery.
From the surgeon's point of view, Chen Yiqing is 45 years old, and his physical function has begun to decline. The possibility of blood clots and hardening of blood vessels is increasing. The risk of surgery is much higher than that of Zhang Li, who is in her 20s.
"Hey, what am I thinking about? What time is it? I'm still thinking about surgery, so I need to persuade these two people to stop thinking about it."
Jian Lianyun suddenly came to his senses, and when he looked up, he saw four people talking to each other, expressing fierce opinions.
"This..." Seeing this situation, she didn't like to quarrel, so she shrank her head and stopped talking.
Suddenly, there were two bangs.
Chen Yiqing patted the table and said loudly: "Stop arguing, yes, it's the two of you."
"Anyway, Lily and I have to choose one. If it doesn't work, let's vote."
Wen Renlong was like a duck being strangled by the neck, suddenly lost his voice, and sat back silently.
"Very good. Voting begins." Chen Yiqing looked around, nodded with satisfaction, and said, "Those who agree with me being the test subject, raise your hand."
The venue was silent, no one raised their hands.
After a while, Wen Renlong raised his right hand slowly, and as soon as he raised it above his head, Zhang Li gave him a hard look, which made him put his hand down quickly in fright.
Chen Yiqing raised his left hand, while his right hand made a note: "One."
"Wang Dali, Doctor Jian, you two can't abstain, you have to show it."
Wang Dali said with a dry smile: "This is too sudden, I'm still thinking about it."
Chen Yiqing looked at him, smiled slightly, and said, "Since I only have my vote, the four of you left must be on Lily's side."
"Very good, there is no need to vote anymore, the voting is over, I have one vote, Lily has four votes, and she is the only test subject."
"What?" The others looked at him in shock, unable to react for a while.
"It's just messing around. You're messing around like this. I don't agree." A few seconds later, Wen Renlong was the first to jump out to object.
"Objection is invalid! I am the person in charge of the project, and I have the final decision." Chen Yiqing suppressed him extremely forcefully.
"Okay, it's decided like this. The human body test will start in the afternoon. Lily, make preparations." Chen Yiqing looked at Zhang Li and ordered with a smile.
When Wen Renlong saw the sly look in Chen Yiqing's eyes, he reacted instantly and became furious.
"The two of you are together, and you are making fun of me."
Wang Dali patted his head, and suddenly realized: "Chen Bo, in fact, you have wanted Lili to be the test subject for a long time, and you were afraid that we would disagree, so you came here like this, tsk tsk, this skill is really good, the knowledge of opening windows You figured it out."
"I originally wanted to abstain from both of you, but in the end, you saw through me." He sighed with regret.
"Hehe, I was afraid that you would abstain, that's why I did it." Chen Yiqing chuckled.
"Anyway, your performance just now has revealed your inner thoughts. Between me and Lily, you are more willing to choose her. That's why you didn't raise your hands when facing me. This subconscious expression is actually more real."
Wang Dali was silent for a moment. He had to admit that the other party was right. If he really had no choice, he could only vote for Lily. The reason was very simple, and it had nothing to do with age, just because Chen Yiqing was the project leader.
Jian Lianyun on the side was stunned and speechless. She had really thought about it seriously. She had to choose someone. She could only vote for Zhang Li. After all, she was young and an assistant, so he was not that important in the project.
Wen Renlong stopped talking, he could tell that among the five people present, he was the only one who really opposed it, so no matter how much he protested, it would be meaningless and he could only accept this reality.
"Then after the experiment is over, can the equipment be taken out? Lily can't keep this thing in her mind."
He asked one last question.
Chen Yiqing pondered for a moment and gave an affirmative answer.
"Don't worry, the connecting wire and the nerve chip can be taken out. As for the stent, it may grow together with the blood vessel wall after a long time. It is very difficult to take it out, but the mesh is very sparse. The diameter of the large vein we implanted is relatively large. The overall risk is controllable."
"That's the only way to go." Wen Renlong sighed and accepted the result helplessly.
He looked at Zhang Li, as if he was meeting her for the first time, and began to look at her carefully.
That oval face, which is not glamorous, but quite attractive, has no apprehension or worry, but only excitement and anticipation. The whole face is like white jade, glowing with a strange intertwined youth and knowledge. beauty.
Wen Renlong looked and looked, but for some reason, he couldn't look away for a long time.
"This woman is beautiful, but she's really ruthless." He trembled all over, and this idea suddenly came to his mind.
******
Interventional brain surgery for humans is naturally different from monkeys. It cannot be done in a laboratory, but can only be done in a qualified hospital.
Fortunately, the No.1 Minority Hospital in Kunming is a senior partner of Sanqing, and Jian Yun is the second in command of the department. The brain-computer interface belongs to the joint innovative scientific research project of the two parties. The hospital attaches great importance to it and sent the most sophisticated surgical team.
The surgery was minimally invasive and went well.
It only took half a day from anesthesia to suturing, closing the eyes and opening them again.
Zhang Li was able to get out of bed and walk around that night, but just to be cautious, she was kept in the ward for another three days for observation.
Three days later, when she was discharged from the hospital, the 2 mm wide incision on the back of her neck was almost healed.
During this time, everyone was busy installing large hardware facilities, designing new computer programs, and fixing various minor problems.
And just like that, it was time for the first human test.
In the laboratory, Zhang Li sat quietly on a chair as usual, with a joystick, a flat-screen LCD monitor, and a juice supply machine in front of her.
The same video game also starts with whack-a-mole, and even the actions are exactly the same.
She only needs to move her arm, grab the joystick, control the moving stick on the screen, and hit every gopher violently, and she can enjoy the juice to her heart's content.
As long as a crit action is completed, the juice machine will spout a small glass of her favorite orange juice.
Not far behind, there are rows of computers and monitors on the workbench.
Her brain activity will be recorded and wirelessly transmitted to a computer for further study.
According to the new algorithm, it is converted into a digital electrical signal and sent to the next-door robotic arm to complete a whole set of the same process.
everything's ready.
(End of this chapter)
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