I can extract side effects.

Chapter 357 Breakthrough of CCR5 Antagonists
Late at night, Sanqing R&D Building.

Wen Renlong stretched, yawned big, pushed open the office door, and walked out.

His hair was disheveled like a bird's nest, his messy shirt was stained with a few suspicious stains, and it also exuded a strange smell, his eye sockets were sunken in big dark circles, and he looked haggard and tired.

There is only one pair of eyes, but they are still bright and energetic, and there is no trace of tiredness.

He strode toward the biological laboratory downstairs, and when he came to a lighted office, he seemed a little tired, too lazy to stretch out his hand, and flew over skillfully, kicking open the half-hidden door.

"What's the matter?" Tang Que asked without raising his head. As soon as he heard the movement, he knew that there would be no one else except Wen Renlong.

Wen Renlong walked in excitedly, stared at Tang Que with burning eyes, stretched out two fingers, and made a V.

"Old Tang, CCR5 antagonists have finally made a qualitative breakthrough."

"With my three days and three nights of sleepless efforts, this medicine is ready."

"Oh?" Tang Que became interested in an instant, and stretched out his hand: "Show me."

Wen Renlong took out a tablet from his pocket, clicked it a few times, handed it over, and began to introduce it incessantly.

"SQW1385 is a highly specific CCR5 antagonist with high affinity. It can bind to the 5, 1, 2, and 3 transmembrane regions of CCR7 to change the conformation of the extracellular region of CCR5, and can effectively antagonize Induction of RANTES."

"In vivo experiments in rodents and primates showed that it has an oral bioavailability of 70%, a plasma half-life of 8 hours, and significantly reduced replication of the R5 strain."

"However, in the follow-up animal experiments and in the derivation of AICell's clinical trials, it was found that high concentrations would cause some damage to the kidneys, and long-term use would lead to adverse reactions of renal failure."

"So I used AI modeling to modify its structure, obtained a series of compounds, and obtained a derivative small molecule antagonist SQW26746, which has 1385 times higher antagonistic activity than SQW20."

"The current derivation in AICell shows that SQW26746 has up to 10 times the biological activity, and has no adverse reactions such as kidney damage. It has good pharmacokinetic properties, 100% biopharmaceutical efficiency, and up to 90% drug binding rate. Moreover, it will not cause inhibitory reactions to liver enzymes, and will not cause liver toxicity."

"In vitro activity experiments have also proved this. In the animal experiments of genetic mice and monkeys, this drug has a very strong inhibitory effect on HIV virus."

"Although the data of this drug seems to be perfect, the 90% binding is still not up to my high standard of 100%."

Wen Renlong's self-satisfied tone suddenly changed, and he said lightly.

"Fortunately, with your assistance, a macromolecular peptide antagonist was added, which is a short peptide containing 41 amino acids with high affinity, and can block the activity of HIV virus by binding to CCR5. "

"Although it is not very stable, after adding an auxiliary agent, it can already take effect through oral administration and achieve a perfect complementarity with SQW26746, which can have a high binding rate of 100%."

"At the same time, I also added inhibitors of other links in it, which can have an all-round lore effect on the replication and spread of the HIV virus."

"This new anti-HIV drug, I named it Jueqing Duanailing. If you take it, you will be able to stop love and Jueqing, and all evil will not invade, and you will be reborn from nirvana."

Tang Que listened carefully at the beginning, but at the end, he couldn't hold back and let out a burst of laughter.

"Have you read too many novels and become dazed? Can you give me a normal name?"

Wen Renlong thought seriously for a second and said, "The name Juqing Duanailing is a bit long, or it should be called Duanailing."

"I quite like this name. It's very emotional. It must be easy to remember. Didn't the boss promise us that we can have the naming rights of our own research and development drugs? He probably won't refuse me."

Tang Que's mouth twitched, and he spread his hands and said, "Anyway, there are three names for medicines. There are standards for chemical names and generic names. You must not be allowed to fool around. Only the product name is determined by us, so it's not casual."

Wen Renlong curled his lips and said: "I have developed such an awesome drug, I must have the right to name it, otherwise I will not be reconciled. Since we want everyone to know that this drug was developed by me, the name must have a personal style and Unique, how can I do it if I don’t show off the style.”

"What bevacizumab, osimertinib, telmisartan, dexamethasone, iprozhen hydrochloride, omeprazole? Who remembers these names except us?"

"What dexamethasone, believe it or not, the patient can call it tiramisu for you."

"How can my Duan Ailing be so good, catchy and easy to understand."

Tang Que said unhappily: "Please, didn't you name SQW26746? Isn't that W the first letter of your name?"

"Cut, it's just an internal code name, except for the hard drive, ghosts can't remember it." Wenren Long Zhen said eloquently.

A drug usually has multiple different names from research and development to marketing.

In the research and development stage, the drug will have a code name used to represent the compound, such as SQW26746. Sometimes it will be called 26746 directly to save trouble.

After successful research and development, the drug will have a generic name, which is the legal name of the drug approved by the State Food and Drug Administration, which is equivalent to the official name on the child's ID card. Various common names of drugs that are unknown in the hospital fall into this category. .

When it goes on the market, pharmaceutical companies will give the drug a trade name, such as Ganmaotong, Changchongqing and other easy-to-understand names.

Patients generally go by the brand name, because unless it is a familiar name like ibuprofen and aspirin, the generic name is too confusing and difficult to understand.

That's why Wen Renlong is so concerned, he wants to take a popular name and imprint his own deep imprint on it.

After all, the market for anti-AIDS drugs is extremely broad, and it is easy to produce a blockbuster that is famous all over the world. Cocktail therapy is famous because it is easy to understand.

Thinking about the name 'Duan Ailing' which was about to spread all over the world, he couldn't help but feel itchy in his heart, as if he had been electrified, feeling extremely refreshed.

clap clap!

Tang Que was too lazy to talk to him, so he lazily raised his hand and clapped his hands, interrupting his reverie.

"Hey, Aaron, you are so outstanding. An outstanding man like you, no matter where he is, is like a firefly in the dark, so bright and outstanding."

Wen Renlong immediately raised his head and chest: "Call me Brother Long."

Tang Que suffocated for breath, his teeth itched a bit.

He suddenly stretched out his right hand, waved it under his nose, and asked with a frown.

"What kind of smell is this? Why is it so stinky? You just said that you stayed up for several nights? Did you never take a shower? This is too sloppy."

Wen Renlong said awkwardly: "Scientists can be called sloppy. Brother Que, I'm so sleepy, I have to go back and catch up on sleep, and report to the boss tomorrow."

"I'm leaving first, please don't keep me, I know you are very interested, but I really don't have time. If you want to know more details, come and ask me tomorrow."

Wen Renlong waved his hand swiftly, turned around and left, and disappeared outside the door in an instant.

Tang Que shook his head and turned his gaze to the computer.

The successful development of Wen Renlong's CCR5 antagonist undoubtedly gave him a certain amount of pressure.

He has not forgotten that the research and development routes of the two were in competition at the beginning, and now that the brothers have achieved results, while he is happy, he also has a stronger sense of urgency.

"It is really difficult to knock out the inserted HIV virus gene segment from the patient's DNA."

"After the HIV virus enters the human body, it will quickly replicate in large numbers, infect all cells in the body, and hide everywhere in the body. After the HIV virus in the immune system is eliminated, it will resurface and replicate from the body cells, and it will continue to recur. Endless."

"It's a very cunning virus, and it's very difficult to get rid of it."

"Ordinary genetic medicines can only be treated continuously, and they can never be cured. Both for patients and pharmaceutical companies, the cost is huge. It is better to take antagonists, which are cheap and easy to use."

"The boss's idea is good, and the idea provided by Aaron is also very correct, but so far I have only developed a gene drug that knocks out the gene fragment of the HIV virus. How to wrap the drug in the virus plasmid and then deliver it to the whole body? A tricky conundrum."

"The most difficult thing is to choose a suitable virus, which can not only infect the whole body cells, but also can be modified to remove the toxicity while retaining its infectivity and not causing harm to the human body."

"The most suitable one in this regard is the cold virus, which can be included as a candidate. Let's take a look at the others."

"The current situation is equivalent to that I already have a fatal bullet, but I lack a powerful gun that can send the bullet thousands of meters away to destroy the enemy without affecting my health."

"After making bullets, let's continue to study how to make guns, no matter how difficult it is."

"I can't say that I can't do what I promised in front of the boss."

Tang Que muttered in his heart, facing the computer screen, lost in thought.

******
The next day, Wei Kang was very excited when he learned that the anti-AIDS drug had been successfully developed in his office.

This is the biggest good news before the Spring Festival.

The HIV virus is currently the most difficult virus to kill in the world. Among all the currently known therapeutic drugs, there is no function of killing the HIV virus, and they are all just some inhibitors.

Taking such drugs for a long time, the best result is to keep the virus in the incubation period, and the patient becomes a carrier. Once drug resistance or intolerance develops, it may change from the incubation period to a real AIDS patient at any time.

Although pharmaceutical companies continue to innovate, the survival time of patients becomes longer and longer.

But the pain of having to take medicine for life is still tormenting every patient.

Mainly, the drug side effects of cocktail therapy are very serious, and taking medicine every day is also a kind of trouble.

It is inconvenient for patients to take medicine if they go out to socialize, travel, or do errands.

This disease has a very bad reputation. Unlike anti-inflammatory drugs and health products, it can be widely advertised.

If you go out to eat and bring a box of cephalosporins, everyone will definitely look at you with caring eyes. Not only will you receive a wave of condolences, but it will also stop everyone from toasting.

But if you go out to eat and bring anti-AIDS drugs, [-]% of the people will run away, can't be friends, and will hide when they see you in the future, and your reputation will be bad on the street.

Therefore, most AIDS patients take medicine secretly and dare not let others know, which causes great troubles in daily life.

For these people, AIDS is like a shackle, and the patient is trapped in this shackle every day and cannot be released.

Once the drug is stopped, the virus will rebound wildly.

To myself and to my family, it was like a catastrophe.

The disease has spread globally, especially in the liberal West, and where it originated in the Philippines.

In recent years, the number of AIDS patients in China has also shown an increasing trend. The number has already exceeded one million, and the death toll has exceeded 35.

There is even a trend of younger age, more and more minors and college students are tested positive for AIDS.

In order to help students detect early, HIV test strips began to appear in the vending machines of many colleges and universities.

This disease is not fatal, but it will directly attack the patient's immune system, which is equivalent to breaking the door lock and leaving the door open. In this way, all viruses and bacteria will swarm into the home.

Patients will soon develop various infections, and then die of systemic organ failure.

In the 40 years since its launch, it has killed 2500 million patients, comparable to World War I, and is extremely contagious.

The two attributes of fatality rate and infection rate are full, which can be called the number one assassin of life.

In the past, if you got this disease, you would die, and basically you only had one or two years to live.

With the continuous advancement of technology, it is much better now, and patients can live for 40 to [-] years.

Most of them are transmitted through sex, more than 70% of heterosexual transmission, and more than 20% of same-sex transmission.

The remaining 10% is mother-to-child transmission, blood transmission, etc.

Sexual transmission is fine, but other types of infections are very pitiful, which is equivalent to a sudden disaster. Once infected, the patient's whole life will completely collapse.

There is a village in a certain place in China. Because of poverty, all the villagers donate blood and sell it for money. Unfortunately, the whole village is infected with AIDS, and it has become a famous AIDS village.

As for the baby, it is even more pitiful. At such a young age, he has no choice, and he is born with such a serious illness.

The gene-edited baby incident that once made a lot of noise was that doctors violated ethical regulations and knocked out the CCR5 gene fragment for unborn test-tube babies, so as to achieve the effect of immunity to HIV infection.

In addition, there is another group that is also vulnerable to HIV infection, and that is medical staff.

Every year, there are news reports that medical staff are infected by blood or body fluids during examinations or operations on patients.

In this case, it is generally necessary to take HIV-blocking drugs within the golden time of 72 hours for 28 consecutive days to prevent the virus from spreading to the whole body and eliminate the hidden danger of infection.

Wei Kang has little sympathy for those patients who are infected due to personal problems.

But he has always had compassion for those innocent patients who were infected.

Now that Sanqing has such a special drug, it is undoubtedly great news for those blood donors, babies and medical staff.

At least they can live healthy and healthy all the time.

After taking the medicine Sanqing, it can completely clear the HIV virus in the body, making it no longer contagious, and it will not cause autoimmune diseases.

Because the HIV virus will be embedded in the patient's DNA, there will still be HIV gene fragments in the cells of the patient's body, but all pathways will be completely cut off, and it will not replicate or spread everywhere. As long as you keep eating, you will never Will relapse.

The patient's survival period will be greatly extended, and AIDS has completely become a chronic disease.

In addition, the various combinations of drugs required for cocktail therapy have also been brought together in one drug.

Therefore, patients only need to take one drug, which greatly reduces the interaction and adverse reactions caused by multiple drugs.

Wei Kang greatly appreciated Wen Renlong's work, and agreed to the product name 'Duan Ailing'.

The brainwaves of the two probably matched, and both felt that the name was very easy to understand and catchy, and it must be easy for patients to remember, which is conducive to the promotion of new drugs.

"Great, Aaron, I knew that you never let me down."

Wei Kang was full of smiles, extremely happy, and he did not hesitate to praise him.

"Have you finished all the animal experiments? Your mobility is really extraordinary, you are definitely the best scientist I have ever seen."

Wen Renlong leaned on the office chair, smiling until his eyes narrowed, feeling extremely refreshed.

"Boss, don't worry, it's almost Chinese New Year now. Many employees took leave early and went back to their hometowns, and they all left."

"When they come back in a year, we will start clinical trials immediately." He said carelessly, patting his chest.

"That's right, you are very thoughtful, Aaron, you have worked hard these days, you should take a good rest and have a good year."

Wei Kang nodded in agreement and said: "This is definitely a blockbuster drug, with the strength to hit the king of tens of billions of medicines, and you will be the first to do so."

Wen Renlong scratched his head and grinned: "Boss, in fact, Old Tang also contributed a lot. Both of us have contributed, so let's just split [-]/[-], he is [-] and I am [-]."

"You pay the bonus at that time, don't forget his part."

Wei Kang smiled slightly: "Both of you are great contributors, how can a mere bonus be enough, I will give you project dividends."

"In the future, there will be project dividends for the R&D personnel of this billion-dollar drug."

"I can't give you shares. I have to give you enough money to be worthy of your efforts."

　In fact, the cold virus that is most suitable for modification is a certain crown that is currently raging. If the gene drug is injected into it, it can achieve the goal of a complete cure.Viruses are scary, but if they can be used properly, they are also very useful tools.

　　
　
(End of this chapter)