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Chapter 899 Drug Experiments
After completing the analysis of the cause of leukemia in the Berry Islands, Brunn fell into deep hesitation.

After the oil spill in the Gulf of Mexico, British oil company BP paid up to 200 billion U.S. dollars to set up a compensation fund.The fund will mainly compensate for pollution losses caused by oil spills.However, this fund has only paid 70 billion in compensation so far, and all compensation has been paid to US residents and companies.

Residents of the Berry Islands in the Bahamas not only did not receive any compensation, they did not even know that BP Petroleum had such a compensation plan, and they did not know how to obtain compensation.

The main force in claiming against BP is the five US states along the Mexican coast.Includes Alabama, Florida, Louisiana, Mississippi and Texas.But no other Caribbean country, even those affected, including Cuba, has received a penny in compensation.

No one has been able to prove that the Florida Current was connected to the rise in benzene in marine life around the Bahamas, much less that the benzene rise was due to the leak of 970 million gallons or even 300 million gallons of crude oil.

Even if the connection between them seems so obvious and direct.

And something even more chilling is yet to come.

Since the oil spill, a group of American pharmaceutical companies have appeared in Florida like sharks smelling blood.They frequently contacted various NGOs that provide humanitarian and basic medical services in the Caribbean region, and obtained a large number of new leukemia patients' data through large-scale funding and even acquisitions.

Red Caribbean is also one of the NGOs these companies are trying to reach.But fortunately, Red Caribbean's funding source is relatively stable, and they have the confidence to refuse such a request.

What Brunn hesitated was whether or not he wanted to get involved in this matter.In the United States, finding trouble for a big company often means finding trouble for yourself.And now Brunn, who has "reduced" to become an itinerant doctor, really lacks the courage to make trouble for himself.

He just wanted to continue working as a doctor in peace, and then find an opportunity to return to the front line of ER to wrestle with death. Being an ordinary physician is really exhausting.

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"There are many companies looking for residents on the island to conduct experiments." Due to the adjustment of the tour plan, it has been half a year since Brunn set foot on the Berry Islands again.He didn't forget his promise to bring a bunch of food to the island.When he saw the wheat-skinned girl at noon, Bruen keenly noticed that her complexion was not very good.In order to break some strange embarrassment and silence between the two, Bruen had nothing to say, "I did some research before, and there are quite a lot of pharmaceutical companies that want to do experiments here."

"It's a lot." The wheat-skinned girl was silent for a while, then put down the kitchen knife for cutting chicken and said, "I'm going to participate in the experiment too."

"You?" Bruen was startled, "Why do you..."

"I also have leukemia." The girl smiled, "The doctor who came last week gave me a bone piercing, and just informed me the day before yesterday that M4a is a high risk. There is no suitable target, and under the existing treatment plan... I About a year away."

Brun fell silent. He was an emergency doctor.He could wrestle with death in the emergency room, and he could kneel beside the bed and perform high-quality chest compressions for 25 minutes, but he didn't know how to talk to this girl who had only one year to live.

"I have already signed an experiment agreement with a company." The girl turned away and continued to divide the chicken brought by Brunn. "The experiment period is three weeks, and they will give me a new drug. Then pay me Five hundred dollars." Her voice sounded...actually a little happy, "With this money, our boat can be repaired."

Bruno didn't even remember what he ate that day.He only remembered that after he returned to Orlando, he didn't sleep for a whole night.

Bruen didn't know the girl's name, but he did see a diagnosis from an Orlando hospital. The diagnosis of M4a leukemia should be no problem.And the company that signed the experimental enrollment agreement with her... is a company that focuses on the research of PD-1 treatment options.According to Brunn's understanding, PD-1 treatment is a new type of immunotherapy, and its effect is mainly on solid tumors.

The PD-1 treatment plan is mainly aimed at Hodgkin's lymphoma or large B-cell lymphoma in blood diseases. It is not very effective for a series of acute myeloid leukemia (AML) including M4a type.

In a recent treatment trial, the overall response rate of PD-1 monoclonal antibody application in patients was only 33%, and the complete remission rate was about 15%.

Moreover, since most potential antigen targets are present in normal hematopoietic stem cells, whether it is PD-1 or CAR-T therapy, it is possible to increase or even cause more severe hematopoietic toxicity.

Antibody therapy for acute myeloid leukemia patients is not the most suitable treatment plan for them, even in principle.

For the next week, Bruen flew to the Berry Islands with food almost every day, but he couldn't find the girl with the wheat complexion and the bright smile.It wasn't until a month later that he saw her again in Red Caribbean's office.

Her smile disappeared, and her wheaten complexion took on an unhealthy yellow tinge—she developed jaundice.

"The treatment is over." The girl was still smiling hard after seeing Brunn, "I got the money."

"..." Bruen didn't say a word, he could tell that her complexion was very bad.That's not a good sign.

"The doctors said I had no signs of remission. So, they prepared me a course of chemotherapy drugs." She struggled to bring up the food Brunn brought, "I'm leaving for Nassau tomorrow—listen Said the place was beautiful."

Nassau is the capital and largest city of the Bahamas.

"The doctors have given me a lot of medicine." Seemingly sensing that Bruen was in a bad mood, she tried to smile and said, "I secretly looked at the medicine bottles they used, and every hour, they would Give me a 50 mg monoclonal antibody injection. Although I have been using it for three weeks,...God has not smiled at me." Her expression gradually dimmed, "I...I still have a lot of things to do... "

(End of this chapter)