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Chapter 742 Possibilities
Chapter 742 Possibilities
Time is another key in this case.
Tang Min's symptoms began to progress again - this morning's MRI showed signs of expansion of the previous low signal area.The doctors in the imaging department compared it for a long time before confirming that the two low signal areas had expanded by about one millimeter.
Despite all the progress in imaging, Tang Min himself does not show any discomfort at present.She was the same as usual, depressed but fine.However, the progress in imaging made all the doctors who were concerned about the progress of her condition "click" in their hearts.
After being hospitalized, Tang Min received a full set of medical supervision.Even the food she eats every day is actually jointly adjusted and formulated by the Department of Rheumatology and Immunology and the Department of Nutrition - based on Tang Min's previous abnormal immunological tests, they deliberately chose a combination that would not induce allergic reactions.It may seem like a big deal, but the doctors still want to avoid any discomfort for her - no one knows if these discomforts will aggravate the condition again.
As a result, he was very careful, but Tang Min's symptoms started to progress again after he was admitted to the hospital.Moreover, according to previous imaging records, this progress occurred after she was admitted to the Fourth Hospital—before she was admitted to the Fourth Hospital, several low-signal areas in her brain only expanded by 2mm within three months.
Rapid progress in a short period of time is a matter that requires high attention.But Sun Li'en and the others studied together for a whole afternoon, but they still couldn't determine what was causing the progress.
"We basically didn't use any medicine for her..." Zhou Ce, who was haggard after the director's ward round, looked even more haggard after studying the various inspections all afternoon.He looked at the thick examination report and only two lines of medication records and moaned, "How do you think this kind of lesion occurs? Will the magnetic influence of MRI cause the organic lesion to deepen?"
"Since seeing this patient, I feel that the knowledge I have learned is not enough every day." Sun Lien put down the materials at hand, and then pulled his hair in pain. "The AQP4 protein that Dr. Yuan mentioned at noon today, I heard the teacher talk about it a few times when I was in school. The specific mechanism and so on... My eyes are darkened."
"Finally there's something you don't know." Xu Yourong turned on the taunting mode on the side, and she was a little overwhelmed by this responsible job—especially after she just finished a difficult neurosurgery operation . "I thought you knew everything, Team Leader Sun."
Sun Li'en glanced at Xu Yourong with some guilt, he already knew that his basic knowledge was not solid enough.Therefore, when following the group, I deliberately supplemented various clinical knowledge for more than a year.But this knowledge... now doesn't seem to be enough.
"I think your standards for Dr. Sun are too high." Dr. Bruen rubbed his stubble-covered face to tickle it, and then excused Sun Lien, "Sun is just a professional Doctors for three years, you can’t expect a new recruit to save the world, can you? Even Hollywood knows that the ones who can really save the world must be the veteran marines who have experienced battle.” He put down the case in his hand, and then He frowned and said, "Did the patient's family members give her any medicine? I didn't find anything suspicious from the records."
"Definitely not." Sun Lien shook his head. Before entering the hospital, Professor Zhang had already communicated with Tang Min's parents.They also have no intention of seeking any "remedies" or "miracle medicines".On this issue, Tang Min's parents are still very reliable - parents who have reservations about modern medicine will probably not spend a whole year taking their children to many hospitals for treatment.
"It's better for you to be sure." Dr. Brunn knocked on the table to put pressure on Sun Lien, "If the child's parents haven't returned any drugs she has taken, then we can only suspect that it was mannitol or MRI that caused her to suffer. Adverse effects—she hasn't had contrast dye yet."
Yuan Pingan did not participate in their discussion.He was still looking down at various literatures, trying to find relevant papers that supported or opposed his hypothesis.Upon hearing this, Yuan Ping'an suddenly raised his head, frowned and asked, "What?"
Dr. Brunn rolled his eyes, and after repeating what he had said, he added, "I really don't think a 1.5T MRI can have such an impact on the human brain." The implication is , it is probably only mannitol that can cause this effect.
"But... mannitol is a dehydrating agent." Sun Lien frowned and asked, "If the dehydrating agent can cause a change in space, doesn't that mean...these low signal shadows are not edema?"
Hypointense areas are edematous rather than vascularized tumor-occupied areas.This inference is central to supporting Dr. Pascale's diagnosis of anti-AQP-4 antibody-negative NMO.If it is determined that this low signal shadow is not edema, it is tantamount to completely rejecting Pascal's diagnosis direction.
"Who knows." Bruen patted his belly, then continued to lower his head and began to gnaw on the case, "The change in the space occupied by the brain cannot be caused by blood sampling, right? After all other options are ruled out, regardless of the remaining What an incredible choice—it's the right answer. Isn't that a basic principle of reasoning?"
Zhou Ce did not hesitate to pick up Brunn, "The prerequisite is that you can list all the options - we haven't even figured out whether this disease is spontaneous or secondary, congenital or acquired. Two How can you be sure we've listed all the possibilities? What if it's some unknown disease?"
Although it sounded like arguing... But all the doctors present had to admit that Zhou Ce's arguing was actually quite reasonable.
Yuan Pingan pressed a few keys on his computer, and then the whole office heard the sound of printers "creaking and creaking".Accompanied by this sound, Yuan Ping'an stood up and said, "Although I'm not sure yet, I think I've found a plausible possibility."
He walked to the printer and sent the printed paper to Sun Li'en and others.This is a related paper from the Third Affiliated Hospital of Yangcheng Medical College, titled "The Effect of Mannitol on the Expression Level of Aquaporin 4 in Ischemic Cerebral Edema".
"Let's skip the experimental content and look at the conclusion first." He took the paper and said to everyone, "Mannitol has an inhibitory effect on AQP-4."
The paper mentioned in this article is "The Effect of Mannitol on the Expression of Aquaporin 4 in Ischemic Cerebral Edema" by Lin Yongqiang, Xu Zhiqiang, Liu Zifan, Liang Yanling, Kuang Yongfeng, Zhou Borong, etc., published in "Chinese Journal of Stroke" in 2009 Volume 370, Issue 375, pages [-]~[-].
(End of this chapter)
Time is another key in this case.
Tang Min's symptoms began to progress again - this morning's MRI showed signs of expansion of the previous low signal area.The doctors in the imaging department compared it for a long time before confirming that the two low signal areas had expanded by about one millimeter.
Despite all the progress in imaging, Tang Min himself does not show any discomfort at present.She was the same as usual, depressed but fine.However, the progress in imaging made all the doctors who were concerned about the progress of her condition "click" in their hearts.
After being hospitalized, Tang Min received a full set of medical supervision.Even the food she eats every day is actually jointly adjusted and formulated by the Department of Rheumatology and Immunology and the Department of Nutrition - based on Tang Min's previous abnormal immunological tests, they deliberately chose a combination that would not induce allergic reactions.It may seem like a big deal, but the doctors still want to avoid any discomfort for her - no one knows if these discomforts will aggravate the condition again.
As a result, he was very careful, but Tang Min's symptoms started to progress again after he was admitted to the hospital.Moreover, according to previous imaging records, this progress occurred after she was admitted to the Fourth Hospital—before she was admitted to the Fourth Hospital, several low-signal areas in her brain only expanded by 2mm within three months.
Rapid progress in a short period of time is a matter that requires high attention.But Sun Li'en and the others studied together for a whole afternoon, but they still couldn't determine what was causing the progress.
"We basically didn't use any medicine for her..." Zhou Ce, who was haggard after the director's ward round, looked even more haggard after studying the various inspections all afternoon.He looked at the thick examination report and only two lines of medication records and moaned, "How do you think this kind of lesion occurs? Will the magnetic influence of MRI cause the organic lesion to deepen?"
"Since seeing this patient, I feel that the knowledge I have learned is not enough every day." Sun Lien put down the materials at hand, and then pulled his hair in pain. "The AQP4 protein that Dr. Yuan mentioned at noon today, I heard the teacher talk about it a few times when I was in school. The specific mechanism and so on... My eyes are darkened."
"Finally there's something you don't know." Xu Yourong turned on the taunting mode on the side, and she was a little overwhelmed by this responsible job—especially after she just finished a difficult neurosurgery operation . "I thought you knew everything, Team Leader Sun."
Sun Li'en glanced at Xu Yourong with some guilt, he already knew that his basic knowledge was not solid enough.Therefore, when following the group, I deliberately supplemented various clinical knowledge for more than a year.But this knowledge... now doesn't seem to be enough.
"I think your standards for Dr. Sun are too high." Dr. Bruen rubbed his stubble-covered face to tickle it, and then excused Sun Lien, "Sun is just a professional Doctors for three years, you can’t expect a new recruit to save the world, can you? Even Hollywood knows that the ones who can really save the world must be the veteran marines who have experienced battle.” He put down the case in his hand, and then He frowned and said, "Did the patient's family members give her any medicine? I didn't find anything suspicious from the records."
"Definitely not." Sun Lien shook his head. Before entering the hospital, Professor Zhang had already communicated with Tang Min's parents.They also have no intention of seeking any "remedies" or "miracle medicines".On this issue, Tang Min's parents are still very reliable - parents who have reservations about modern medicine will probably not spend a whole year taking their children to many hospitals for treatment.
"It's better for you to be sure." Dr. Brunn knocked on the table to put pressure on Sun Lien, "If the child's parents haven't returned any drugs she has taken, then we can only suspect that it was mannitol or MRI that caused her to suffer. Adverse effects—she hasn't had contrast dye yet."
Yuan Pingan did not participate in their discussion.He was still looking down at various literatures, trying to find relevant papers that supported or opposed his hypothesis.Upon hearing this, Yuan Ping'an suddenly raised his head, frowned and asked, "What?"
Dr. Brunn rolled his eyes, and after repeating what he had said, he added, "I really don't think a 1.5T MRI can have such an impact on the human brain." The implication is , it is probably only mannitol that can cause this effect.
"But... mannitol is a dehydrating agent." Sun Lien frowned and asked, "If the dehydrating agent can cause a change in space, doesn't that mean...these low signal shadows are not edema?"
Hypointense areas are edematous rather than vascularized tumor-occupied areas.This inference is central to supporting Dr. Pascale's diagnosis of anti-AQP-4 antibody-negative NMO.If it is determined that this low signal shadow is not edema, it is tantamount to completely rejecting Pascal's diagnosis direction.
"Who knows." Bruen patted his belly, then continued to lower his head and began to gnaw on the case, "The change in the space occupied by the brain cannot be caused by blood sampling, right? After all other options are ruled out, regardless of the remaining What an incredible choice—it's the right answer. Isn't that a basic principle of reasoning?"
Zhou Ce did not hesitate to pick up Brunn, "The prerequisite is that you can list all the options - we haven't even figured out whether this disease is spontaneous or secondary, congenital or acquired. Two How can you be sure we've listed all the possibilities? What if it's some unknown disease?"
Although it sounded like arguing... But all the doctors present had to admit that Zhou Ce's arguing was actually quite reasonable.
Yuan Pingan pressed a few keys on his computer, and then the whole office heard the sound of printers "creaking and creaking".Accompanied by this sound, Yuan Ping'an stood up and said, "Although I'm not sure yet, I think I've found a plausible possibility."
He walked to the printer and sent the printed paper to Sun Li'en and others.This is a related paper from the Third Affiliated Hospital of Yangcheng Medical College, titled "The Effect of Mannitol on the Expression Level of Aquaporin 4 in Ischemic Cerebral Edema".
"Let's skip the experimental content and look at the conclusion first." He took the paper and said to everyone, "Mannitol has an inhibitory effect on AQP-4."
The paper mentioned in this article is "The Effect of Mannitol on the Expression of Aquaporin 4 in Ischemic Cerebral Edema" by Lin Yongqiang, Xu Zhiqiang, Liu Zifan, Liang Yanling, Kuang Yongfeng, Zhou Borong, etc., published in "Chinese Journal of Stroke" in 2009 Volume 370, Issue 375, pages [-]~[-].
(End of this chapter)
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