I just want to be a quiet scholar

Chapter 698 Technical Regulation

After Qu Gong's training, Shen Qi and others mastered the operation method of XT80.

After Qu Gong left, the door of the biological laboratory of Shen Qi Research Center was closed.

"Han Meng, we are about to start."

"Come on, I'm ready."

Han Meng lay naked on the laboratory table, with tubes all over his body.

Han Meng was the first to edit the prostate cancer gene.

The main operator, Shen Qi, operated the XT80 to knock out Han Meng's harmful mutant gene, and injected the healthy gene into Han Meng's organs.

A gene is a nucleic acid molecule, and every atom, every free radical, and every heterocycle in the molecule plays its own role.

The operation at the molecular level is still going on, and Han Meng's diabetes mutation gene has been corrected.

Major depression, liver cancer, heart failure followed...

57.8% of Han Meng's genes were modified, including those genes suspected to be faulty.

The gene editing operation was successful, and Han Meng did not die directly in the laboratory.

After Han Meng got dressed, he expressed his gratitude to Shen Qi and the brothers: "Thank you, you gave me a new life."

Shen Qi and the brothers expressed their respect to Han Meng: "Thank you for your contribution to science."

From this moment on, Han Meng became a completely new person biologically.

And this gene editing experiment has specific significance and academic value to Shen Qi's research group.

They have verified through practical operations that known diseases of human beings can be prevented through genetic technology.

They have accumulated valuable experimental data through gene therapy on Han Meng.

However, these valuable experimental data cannot form a published paper.

Some scientists have been severely criticized by international organizations for performing gene therapy operations on babies of AIDS patients.

The gene therapy that Shen Qi and the others implemented on Han Meng included many kinds of diseases.

Shen Qi didn't want to quarrel with others, and didn't bother to explain anything, so only the six of them knew about Han Meng's gene therapy, and they wouldn't disclose it to the public.

How can five Ph.D. candidates get their Ph.D.s if they have no published papers?

Shen Qi has already arranged that the next step of work in their biology laboratory can form a series of published papers.

Shen Qi said: "Han Meng, during the process of gene therapy for you, I marked your PYY-3-36, it was just a mark, and there was no modification."

"So what are we going to do next?" Han Meng didn't care that Shen Qi marked his PYY-3-36.It feels great to be a whole new person.

Shen Qi: "We need to extract your current cell samples."

"no problem."

PYY-3-36 is Maishuling, which has a strong regulatory effect on the appetite of the human body, and is also known as the hunger gene.

Everyone has PYY-3-36. In addition to humans, PYY-3-36 has also been found in mice, dogs, chimpanzees and other animals.

Research starvation genes, modify starvation genes if necessary.This is the next research direction proposed by Shen Qi.

The purpose of the research is to verify that since genes that cause diseases can be edited, can non-disease genes also be edited?

In addition to getting sick, people also feel hungry and have emotions. Some people are smart and some are not so smart.

Can these non-disease factors also be regulated at the genetic level?
worthy of study.

A large number of white mice were transported to the biological laboratory of Shenqi Scientific Research Center.

Comparing PYY-3-36 of white mice and PYY-3-36 of Han Meng, they are the same.

In other words, the genes that control hunger in mice are the same as in humans.

Of course, this has already been proved by Professor Bloom in the UK, and Shen Qi and the others are just proving it again.

Bloom's team published a series of papers. They have conducted research on PYY-3-36 for many years and gave a set of detailed animal experiment protocols.

According to a series of papers by Bloom's team, Shen Qi and others carried out starvation gene editing experiments on white mice.

In the control group of white mice, they were not edited. When the food in their bodies was exhausted, their hunger gene produced the corresponding protein, which sent them a signal that they needed to supplement food, so they felt hungry, and they began to look for food and eat.

The white mice in experimental group 1 had their hunger genes modified, and when the food in their bodies was consumed, they did not feel a strong sense of hunger, and they did not look for food.Shen Qi and others put the food in front of them, and they got some appetite and started to eat.

The mice in experimental group 2 had their hunger genes modified according to another setting. They were starving most of the time, and they were actively looking for food and eating it.

The rats in experimental group 3 were the enhanced version of experimental group 1. Their hunger genes were modified to an extreme state, and they lost their sense of hunger. Even if food was put in their mouths, they would not take a bite.They all starved to death.

The rats in experimental group 4 are the enhanced version of experimental group 2. Their hunger genes have been modified to another extreme state. They feel hungry forever, and they have been actively eating.They are all overstretched.

After dealing with the dead bodies of starved and strangled rats, Shen Qi and others conducted a discussion.

"The research results of Bloom's team are correct. By modifying the hunger gene, the appetite of the white mice can be greatly increased or decreased, and in extreme cases, they can be starved to death."

"Would it be the same if you modified the human hunger gene?"

"In theory, modifying human hunger genes can help obese people lose weight, and it can also treat anorexia patients. Obesity and anorexia are also considered diseases. If you do this, it is the same as modifying cancer mutation genes. International The organization still has to be severely criticized."

The doctoral students discussed enthusiastically, but Shen Qi kept silent.After a while, Shen Qi said: "No matter what the attitude of the international organization is, our experiments cannot be stopped. White mice have many genes that are the same as humans, and the hunger gene is one of them. We have proved through experiments that modifying the hunger gene It can affect the appetite of white mice. I think that modifying the hunger gene can also affect the appetite of humans to a certain extent. We will not do hunger gene modification experiments on humans for the time being, and we will return to white mice. I wonder if you have found out that the SHANK3 gene of white mice , the same as human beings.”

Everyone said: "Yes, I found out that the SHANK3 gene is one of the genes that control IQ."

Shen Qi nodded and said: "Then, let's continue to study how to edit the SHANK3 gene of the white mouse to regulate the IQ of the white mouse."

"With regard to the research on editing the SHANK3 gene, there has not been any convincing research results in the world, which is very challenging." Everyone couldn't help looking forward to it, and they believed that Shen Qi must have some mature ideas.

(End of this chapter)