I just want to be a quiet scholar

Chapter 490
"Interaction is necessary." Lao Yan said absently.

Shen Qi spread his hands and said: "Come on, I don't care about feelings, you can figure it out yourself."

Cheng Haonan asked: "Director Shen, the purification of C01B is finished, what to do next?"

The R&D, registration, and sales of a new chemical drug usually have several processes. The first is mechanism research. For example, dopamine secretion in the nucleus accumbens area of ​​the mesolimbic dopamine system is the most basic mechanism of nicotine addiction. Through this mechanism, the physiological effects of nicotine absorbed when smoking tobacco create a strong sense of pleasure, which in turn induces dependence.

Based on this mechanism, R&D teams of scientific research institutions or pharmaceutical companies began to develop compounds. For example, American scientists used the nicotine receptor part of neurons as the primary target of nicotine activity, and synthesized a new type of compound in the laboratory.

By doing this, the prototype of smoking cessation medicine has been produced, but it is not yet ready for marketing.

The latter is done by pharmaceutical companies, who optimize the compound, complete various tests according to the regulations, and then register and sell it.The above-mentioned compounds were commercialized by Pfizer of the United States and successfully registered with the FDA under the trade name Jibishi and put on the market.

In terms of force, it must be the highest in mechanism research, followed by the first synthetic compound in the laboratory.The scientists who win the Nobel Prize mainly come from these fields of research.

It is impossible to win awards by mass-producing drugs, and then registering and selling them, but it can make money.

The basic mechanism of nicotine addiction has been studied.

Shen Qi and the others have now achieved the second step, synthesizing a new compound with smoking cessation effect for the first time in the laboratory, the internal code name is C01B.

Pfizer is a pharmaceutical giant, and they produced the famous aphrodisiac Viagra.

Whether Shen Qi's C01B is better than Pfizer's Jiebishi is still impossible to judge and needs to be tested.

Who will do the testing?
Anyway, Shen Qi and the three of them won't do it.

So what to do next, Shen Qi's suggestion is: "C01B has achieved this step, and the patent right has been generated. If any pharmaceutical company is interested in this patent, we will sell it to whom."

"Isn't this a generic drug?" Lao Yan asked.

Shen Qi said: "It cannot be regarded as a generic drug. Based on the same mechanism, our synthetic route and final product are different from those of the Americans. For us, the work of C01B is over. We can start the next project."

As for the next chemical project, Shen Qi said that organic synthesis will definitely be done. Regarding TM, both of you should think more about it. The principle is to have a certain degree of innovation.

Retrosynthesis is the most basic way of thinking in the design of organic synthetic routes. Chemists first conceive a target molecule (Target-Molecule, TM), and then design the synthetic route in the opposite direction.

Starting from TM, step by step, consider which intermediates can be used to synthesize TM, and then consider which raw materials can be used to synthesize intermediates. The final raw material is the starting material.

There are three basic principles. First, each step has a suitable and reasonable reaction mechanism and synthesis method.Second, the entire synthetic route should be as simple as possible.Third, there are raw materials that can be supplied by the market, and the easier and cheaper the raw materials, the better.

Synthetic route design is a test of the logical deduction ability of chemists, and at the same time, they must be familiar with various organic chemical reactions.

The basis of organic synthesis is a variety of carbon-carbon bond and functional group conversion reactions. So far, chemists have developed thousands of synthetic reactions, and more than 500 commonly used reactions are named after people.

Shen Qi couldn't remember all the names and reactions last year, but this year he can.

As for the purification and detection of reaction products, this is a basic operation, no matter whether you are a chemical expert or a fresh graduate of chemistry, you need to master it proficiently.

Becoming an excellent organic synthesizer is a comprehensive test, and route design is the first and most important step in the synthesis work.

The determination of TM in route design is the beginning of all difficulties.

Shen Qi, Lao Yan, and Cheng Haonan returned to the center and started imagining each other.

What are you imagining?

For a certain purpose, the three of them imagined a target molecular structure.

What kind of use is it?

Is it a good medicine to cure diseases and save lives, or an invisible poison to kill people?

Is it a purification agent of the healing system, or a pollution source of the dark system?

There is no limit in the imaginary stage, and everyone can give full play to their imagination.

The principle of the hypothetical stage is that if the use of the target molecule cannot be determined for the time being, then it should be considered from the aspect of its structural novelty.

Some of the new compounds may already have a certain use, and some may not yet know what use they are, but it is also meaningful to be synthesized because of their novel structure. This kind of compound is called a chemical treasure.

The most attractive and stimulating part of organic chemistry is to discover new structures and create new products.

It's like the work of God.

However, the work of God is not easy. Unfounded and purposeful thinking will inevitably lead to failure and waste of time.

Shen Qi's purpose is very clear. His imaginary TM is either a super interesting new structure like C60 back then, or a chemical drug molecular structure that can treat his wife's disease.

After thinking about it all day, Shen Qi got a headache and couldn't think of it.

Shen Qi's troubles at work disappeared instantly after returning home.

Shen Nuofei is more than seven months old. She crawls around on the carpet in the living room, quite active.

"Wow!" Shen Nuofei opened her mouth and shouted after seeing Shen Qi, she realized that this man was someone very close to her.

"Nuo Fei, it's Papa, it's Papa." Shen Qi squatted on the ground and taught his daughter the pronunciation.

"Wow!" Shen Nuofei yelled with great enthusiasm, but she still couldn't pronounce the sound of "Dad" clearly.

"Nuo Fei, it's Ma Ma, it's Ma Ma." Ouye squatted beside Shen Qi, unwilling to be left behind. I gave birth to the baby and fed the milk. My daughter must learn to be called Ma Ma first.

Shen Nuofei rolled, she was too fat, she couldn't get over half of the roll, and got stuck on the carpet.

Shen Qi helped his daughter complete the roll, pointed to his nose expectantly, and said earnestly, "Baba, Baba."

Ouye pushed Shen Qi away and seized the favorable terrain. She pointed to her forehead and said to her daughter, "Ma Ma, Ma Ma."

Shen Nuofei looked at Shen Qi, and then at Ouye, she looked puzzled.

"Papa, Papa." Shen Qi never tires of it, teasing babies is the happiest time of his day.

"Baby, you're tall, have you finished your mathematics unification work?" Ouye was determined to let his daughter call mom first.

Shen Qi quibbled: "Honey, I can start the rest of the work only after finishing your number theory section! This is the basic procedure. Nuofi is a good boy. My name is Ma Ma, my name is Ma Ma."

"Skin." Ouye smiled, Shen Qi still let her at home.

(End of this chapter)