I just want to be a quiet scholar

Chapter 450 Imitation
The capsule-shaped drug is developed and marketed by Eli Lilly and Company of the United States. The American generic name is reversed, and the Chinese name is Leluoxianfen, and the product name is Yiweisi.

In China, this drug is usually called Leluoxianfen Capsules, a box of twelve capsules, and the domestic price is [-] RMB. Ouye took one capsule a day before pregnancy.

The pill-shaped drug is developed and marketed by Swiss Novartis, and it is called Condoclon in China.

Speaking of this Swiss pharmaceutical giant, the famous anti-leukemia drug Gleevec they produced was once very expensive, known as the sky-high price drug, and caused trouble.

The Condoclon that Ou Ye eats is not cheap, a bottle of [-] RMB, two bottles a month.

Relying on drugs to hold one breath, and retaining a glimmer of hope for the birth of new medical technology, is the greatest motivation for every patient.

However, many patients cannot afford sky-high prices, and medical insurance can reimburse part of the drugs, but cannot afford every drug in the world.

Expensive is expensive, root cause is the key.

Shen Qi operates a chemical experiment instrument to conduct professional analysis of Leroxime and Condoclan. This is a comprehensive operation that requires knowledge of organic, inorganic, analytical and other chemical knowledge and practical skills.

Through experiments, Shen Qi discovered that Leluoxianfen is actually a benzothiaphene-like compound. It costs 800 yuan a pill, and it disappears when you swallow it. It's really expensive.

Women have a stronger immune system than men, which allows women to fight off more infections.

But due to the role of estrogen and progesterone in the immune response, it also makes women more susceptible to autoimmune diseases.

The main function of Leluoxianfen is to regulate estrogen, and it has a good effect on autoimmune diseases in female patients.

The chemical essence of Condoclan is a kind of oxazolidinone compound, which is said to be the best anti-Mersson's anemia drug in the world.

From a scientist's point of view, the so-called high-priced drugs are not so mysterious. Their essence is to obtain chemical products through chemical reactions.

"Chemistry, upgrade to level 12."

"Creature, give me level 12 too."

Zizi!

Tremors!

Shen Qi was dizzy for a few seconds, then returned to normal, and both chemistry and biology were upgraded to level 12.

Level 11 is the standard master level set by the system, chemistry and biology are fortified with points, and the highest level can only be awarded to the high-level master level of level 12.

Level 13 is the master level of the top configuration, and certain conditions must be met in order to be upgraded from the top configuration of level 12 to the top configuration of level 13.

The conditions for upgrading Chemistry 12 to 13 are:
1. 400 million Xueba points or experience points;
2. Obtain any one of the following chemistry awards to prove the master level of the host.

The system pops up a list, which includes: Nobel Prize in Chemistry, Wolf Prize in Chemistry, Welch Prize in Chemistry, International Carbohydrate Prize, International Catalysis Prize... and more than a dozen internationally renowned chemistry prizes.

The conditions for upgrading creatures from level 12 to level 13 are:
1. 400 million Xueba points or experience points;
2. Cultivate at least five excellent biological doctors.

"...The balance is 30012781 Xueba points, please confirm with the host."

The king of mathematics, physics, chemistry and physiology was born today.

Except for Shen Qi, there should be no other people in the world today who have graded 14 in mathematics and physics, and grade 12 in chemistry and biology.

If chemistry and biology want to continue to upgrade, Shen Qi has to achieve academic research results in the real world, or cultivate outstanding young talents.

It is very difficult to win the Nobel Prize in Chemistry at the 12th level, and Shen Qi can fight for other chemistry awards.

It took a lot of time, energy and emotion to bring out 5 excellent PhDs in the field of biology, and Shen Qi first had to obtain the qualification of a doctoral supervisor in biology.

Mathematics, physics, double 14, chemistry, biology, double 12, let's make do with it.

Mathematics, physics, chemistry, and biology are not completely independent. Mathematics points out the direction, physics ignites sparks, chemistry intersperses left and right, and biology follows closely.

When the level of mathematics, physics, chemistry and biology reaches a certain level, it can be integrated and established, which depends on the scientist's perception ability and integration means.

Center 401 experiment, Shen Qi's laboratory alone, he is doing chemical experiments.

"Arylation of boronic acid 43 using a Suzuki coupling reaction."

"Benzothiphene 81 was obtained in 13% yield."

"Recovery of ionic liquid (N-methyl, 4-butylimidazolium tetrafluoroborate) for use in the Friedel-Kratz reaction... ahem!"

During the Friedel-Kratz reaction, a large amount of light red mist is generated in the reaction vessel, which is acidic and pungent.

Even though Shen Qi was wearing a mask, he couldn't help coughing. While coughing, he read the chemical literature.

It is written in the literature that Friedel-Kratz responded that it was like this, and the experimenter was asked to wear a full set of chemical protective equipment and keep the laboratory ventilated.

The Friedel-Kratz reaction is named after the two chemists who first discovered and reported it.

There are too many personal name reactions in organic synthesis, and it is difficult to remember all the personal name reactions and their principles and phenomena.

Shen Qi continued his chemical synthesis experiments.

"79c with the complete skeleton of Renoxifene was obtained in 28% yield."

"Introduction of 2-hydroxyethylpiperidine side chains via a copper-catalyzed coupling reaction."

This reaction again used an ionic liquid (N-methyl, 4-butylimidazolium tetrafluoroborate).

Chi Chi!

The acidic and pungent reddish mist diffused for the second time.

Shen Qi also understood the strangeness, and developed psychological resistance.

Finally, in a Lewis acidic ionic liquid (trimethylaminoaluminum trichloride), Shen Qi obtained Leluoxianfen with a yield of 43%.

Leluoxianfen capsules are sold on the market at 9600 yuan per box, and 800 yuan per capsule.

Shen Qi synthesized Leluoxianfen in his 401 experiment by studying the instructions of Leluoxianfen capsules and related chemical literature, using the actual Leluoxianfen capsule as a sample reference.

Theoretically, this is the case, if Shen Qi's experimental procedures are correct.

Eli Lilly of the United States would definitely not tell Shen Qi the specific technical details of Le Luoxianfen's preparation. Shen Qi reversed the derivation and obtained Leluoxianfen.

Whether Shen Qi's version of Le Luoxian has the same curative effect as the American version of Le Luoxian needs further verification.

Even if Shen Qi succeeded in imitating Le Luoxianfen, he would not be able to sell it, because Eli Lilly and Company of the United States had already applied for a global patent for this drug.

There should be a few chemists in the world who possess Shen Qi's reverse derivation ability and operation level.

There is basically no difference between Gleevec produced by Indians and Swiss Gleevec. Facts have proved that cheap Indian Gleevec can also save leukemia patients. There must be chemical experts in Indian folk.

"Leluoxianfen, are you really effective?" Shen Qi observed his homemade Leluoxianfen, which his wife had been taking for many years.

It is very important for Shen Qi to verify the toxicology, pharmacology, pharmacokinetics and drug metabolism properties of the self-made version of Leluoxianfen.

If Shen Qi successfully synthesizes the medicine that Ouye has been taking for a long time in the laboratory, it will give Shen Qi great confidence. Maybe one day, he will be able to synthesize a new drug with better efficacy.

According to the report of Eli Lilly and Company of the United States, they did pharmacological and toxicological experiments on white mice and monkeys during the development stage of Leluoxianfen, which verified the safety of Leluoxianfen and passed the FDA (US Food and Drug Administration) ) certification, to obtain listing sales qualifications.

"Monkeys? Where can we get monkeys? Monkeys are all nationally protected animals." Shen Qi was lost in thought. It is easy to apply for white mice, but it is not easy to get primates used for animal experiments. You have to ask the Department of Medicine or the Academy of Life Sciences for help.

(End of this chapter)