Chapter 445 Toxicology
Shen Qi Mathematics and Physics Research Center began to relocate from the third floor of the mathematics building to the newly built central building.

Finally, we have our own independent research base, and the staff of the center are very excited.

Shen Qi made a simple arrangement in Room 401 on the fourth floor, and he asked Yang Dingtian to help him tidy up Room 401 together.

The FASTER project team is engaged in the research of amorphous materials, dealing with various chemical elements every day, and already has some basic chemical instruments and raw materials.

Electronic balances, beakers, volumetric flasks, straws, triangular beakers, projection electron microscopes, ultrasonic suspension instruments...these common instruments are all available.

Shen Qi purchased additional syringes, gavage needles, glass specimen bottles, and planing instruments such as planing boards, surgical scissors, tweezers, and hemostats.

Yang Dingtian discovered the problem: "Academician Shen, these planing instruments should have nothing to do with condensed matter physics experiments, right?"

"Basically there is no connection. By the way, you have an orange cat in Dingtian, and you know a lot about experimental animals. Help me buy 10 Wistar rats and 10 KM mice."

"Academician Shen, Laplace is a pet and our friend, it is not a laboratory animal!"

Yang Dingtian could see that Shen Qi was going to experiment on animals.

Many people said that Yang Dingtian was a weirdo with mental problems.

Weird people have one advantage. What other people think is strange, he thinks that's the case, and it's not worth making a fuss about.

Yang Dingtian quickly helped Shen Qi get 10 Wistar rats and [-] KM mice each. These two strains of white mice are widely used in various animal experiments.

Shen Qi stroked the white mice gently, then put them back into their cages, and entertained them with food and drinks.

"Dingtian, soon I will go to Sweden to attend the Nobel Prize awarding ceremony. When I'm not here, help me treat these white mice well. Don't let your cat eat the white mice. These white mice belong to scientific research assets." Shen Qi told Yang Dingtian.

Yang Dingtian accepted the task: "Don't worry, Laplace only eats cat food and canned food. He hates mice the most."

Shen Qi continued to explain the details: "In a sense, animal experimentation is a cruel thing, but for the sake of science, we must do it. In the process of raising animals, we cannot cause animals to suffer unnecessary harm and discomfort. , hunger, panic, torture, pain and disease, to ensure that animals can achieve natural behavior, are well managed and cared for, and that individual animals are in a state of well-being at all times."

Yang Dingtian nodded: "Okay."

In fact, Shen Qi also knows that anyone who enters Laboratory 401 can see that the scientific research tasks undertaken by this laboratory have nothing to do with physics.

What is the purpose of Shen Qi's animal experiments, Yang Dingtian did not ask in detail.

Shen Qi's original intention was to develop a medicine to cure his wife's illness.

How to explain this kind of thing, if Shen Qi uses national scientific research resources to serve his wife alone, it is a violation of discipline.

Rising to a higher level, if Shen Qi serves patients with chronic diseases of the immune system and blood system all over the world and provides effective scientific solutions, it will no longer be for the benefit of the public, but will benefit all mankind.Ouye is not the only one suffering from this disease in the whole world.

Before developing drugs, we must first reserve experimental animals to cultivate the relationship between humans and animals, so that the animals are in a happy state.

Three-drug.

Thalidomide has caused more than 12000 infant seal limb deformities in Britain, France and Germany, and subacute myeloptic neuritis caused by clioquinol has caused tens of thousands of people to be disabled and nearly a thousand people to die in Japan.

The eye-skin-mucosal syndrome caused by pralolol produces 100 million cases every year worldwide.

The hemolytic anemia and renal failure caused by timafloxacin have caused the United States, Canada, Australia and other developed countries to suffer a lot.

The elevated blood pressure and arrhythmia caused by phenylpropanolamine hydrochloride, and the heart attack and stroke caused by the non-steroidal anti-inflammatory drug rofecoxib have also caused Chinese patients to suffer harm.

There are many similar drug injury incidents. These well-known drugs are developed and produced by famous European and American pharmaceutical companies such as Bayer in Germany and Merck in the United States. They are widely sold around the world, causing large-scale patient injury or even death.

Drugs are originally used to treat diseases and save lives, but while drugs have positive effects on target organs, they may also cause serious side effects on other human organs.

So the scientific significance of toxicology is very important.

The meaning of toxicology is "toxicological research". Modern toxicology studies the harmful (toxic) effects of the body exposed to chemical, biological, and physical substances under specific circumstances.

Drug toxicology is a branch of toxicology, which mainly studies the inevitable systemic or local pathological changes of the body caused by drugs in the process of human beings using drugs to prevent and treat diseases, and even cause irreversible damage or lethal effects.At the same time, it also studies the safety and risk assessment of new drugs before they go on the market.

Shen Qi is currently focusing on the branch of drug toxicology, which is mainly supported by chemical and biological knowledge.

The wife's body is already very fragile, and can no longer withstand additional damage.

Before making medicines, one must first master various toxicological properties. This is an experimental science, and Shen Qi must do it himself to improve his proficiency in skills.

Shen Qi did what he said, and the experimental animals he chose were male mice, weighing 18-22 grams.

Firstly, the mice were infected with the pesticide atradine, and then 5% SRBC 0.4ml serum was injected into the abdominal cavity of the mice for immunization.

Shen Qi's purpose of injecting immune serum after exposure was to conduct a hemolytic plaque experiment, which is an immunotoxicity experiment.

The infected mice are still living happily, and Shen Qi observes the living conditions of the experimental mice every day.

Until the fourth day, the experimental mouse showed symptoms of discomfort. Its short life is coming to an end, but its scientific mission will continue.

Shen Qi put on protective gloves and a mask, and took the mouse out of the cage.

The mouse had started to twitch slightly, and Shen Qi needed to end its pain as soon as possible.

Spinal dislocation is an effective way to end the suffering of laboratory animals.

Shen Qi grabbed the mouse with his right hand and pulled it back forcefully. At the same time, his left thumb and index finger pressed down on the mouse's head. This simple operation was to break the mouse's spinal cord and brain, causing the mouse to die immediately.

Click!

Shen Qi made a move, and his technique was sharp.

He closed his eyes and mourned for a second, this is a life after all.

Scientists must respect life, and although they will terminate some lives, respect for life is indispensable.

Squeak!

The clicked mouse did not die immediately, it twitched even more painfully.

What the fuck?

Shen Qi was embarrassing, it was the first time to perform the spinal dislocation method, the strength was in place, but the pulling angle was slightly off.

Click!

Shen Qi performed spinal dislocation on the mice again, this time it was successful, and the mice were killed.

Shen Qi picked up the surgical scissors and tweezers, quickly cut open the abdomen of the dead mouse, and took out the spleen.

Shen Qi had never killed a chicken before, this was the first time in his life to disembowel a chicken, and it required him to quickly and accurately remove the internal organs of the animal.

Feeling a little nauseous, Shen Qi still held back.

(End of this chapter)

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